Host DNases prevent vascular occlusion by neutrophil extracellular traps

doi:10.1126/science.aam8897

GSTDTAP > 地球科学

DOI	10.1126/science.aam8897
	Host DNases prevent vascular occlusion by neutrophil extracellular traps
	Jimenez-Alcazar, Miguel 1; Rangaswamy, Chandini 1; Panda, Rachita 1; Bitterling, Josephine 1; Simsek, Yashin J.1; Long, Andy T.1; Bilyy, Rostyslav 2; Krenn, Veit 3; Renne, Christoph 4; Renne, Thomas 1,5,6; Kluge, Stefan 7; Panzer, Ulf 8; Mizuta, Ryushin 9; Mannherz, Hans Georg 10; Kitamura, Daisuke 9; Herrmann, Martin 11; Napirei, Markus 10; Fuchs, Tobias A.1,5,6
	2017-12-01
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2017
卷号	358 期号:6367 页码:1202-+
文章类型	Article
语种	英语
国家	Germany; Ukraine; Sweden; Japan
英文摘要	Platelet and fibrin clots occlude blood vessels in hemostasis and thrombosis. Here we report a noncanonical mechanism for vascular occlusion based on neutrophil extracellular traps (NETs), DNA fibers released by neutrophils during inflammation. We investigated which host factors control NETs in vivo and found that two deoxyribonucleases (DNases), DNase1 and DNase1-like 3, degraded NETs in circulation during sterile neutrophilia and septicemia. In the absence of both DNases, intravascular NETs formed clots that obstructed blood vessels and caused organ damage. Vascular occlusions in patients with severe bacterial infections were associated with a defect to degrade NETs ex vivo and the formation of intravascular NET clots. DNase1 and DNase1-like 3 are independently expressed and thus provide dual host protection against deleterious effects of intravascular NETs.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000416584000045
WOS关键词	SYSTEMIC-LUPUS-ERYTHEMATOSUS ; INNATE IMMUNITY ; CELL-DEATH ; THROMBOSIS ; DEGRADATION ; CHROMATIN ; BACTERIA ; FEATURES
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/197451
专题	地球科学资源环境科学气候变化
作者单位	1.Univ Med Ctr Hamburg Eppendorf, Inst Clin Chem & Lab Med, Martinistr 52, D-20246 Hamburg, Germany; 2.Danylo Halytsky Lviv Natl Med Univ, Pekarska St 69, UA-79010 Lvov, Ukraine; 3.Hlth Care Ctr Histol Cytol & Mol Diagnost, Max Planck Str 5, D-54296 Trier, Germany; 4.Grp Practice Pathol Wiesbaden, Ludwig Erhard Str 100, D-65199 Wiesbaden, Germany; 5.Karolinska Inst, Dept Mol Med & Surg, Solna L1 00, S-17176 Stockholm, Sweden; 6.Univ Hosp, Solna L1 00, S-17176 Stockholm, Sweden; 7.Univ Med Ctr Hamburg Eppendorf, Dept Intens Care, Martinistr 52, D-20246 Hamburg, Germany; 8.Univ Med Ctr Hamburg Eppendorf, Med Clin 3, Martinistr 52, D-20246 Hamburg, Germany; 9.Tokyo Univ Sci, Res Inst Biomed Sci, Yamazaki 2669, Noda, Chiba 2780022, Japan; 10.Ruhr Univ Bochum, Fac Med, Dept Anat & Mol Embryol, Univ Str 150, D-44801 Bochum, Germany; 11.Friedrich Alexander Univ FAU Erlangen Nurnberg, Dept Med 3, Univ Klinikum Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany
推荐引用方式 GB/T 7714	Jimenez-Alcazar, Miguel,Rangaswamy, Chandini,Panda, Rachita,et al. Host DNases prevent vascular occlusion by neutrophil extracellular traps[J]. SCIENCE,2017,358(6367):1202-+.
APA	Jimenez-Alcazar, Miguel.,Rangaswamy, Chandini.,Panda, Rachita.,Bitterling, Josephine.,Simsek, Yashin J..,...&Fuchs, Tobias A..(2017).Host DNases prevent vascular occlusion by neutrophil extracellular traps.SCIENCE,358(6367),1202-+.
MLA	Jimenez-Alcazar, Miguel,et al."Host DNases prevent vascular occlusion by neutrophil extracellular traps".SCIENCE 358.6367(2017):1202-+.