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DOI | 10.1126/science.aan6836 |
Antibody-dependent enhancement of severe dengue disease in humans | |
Katzelnick, Leah C.1; Gresh, Lionel2; Halloran, M. Elizabeth3,4; Carlos Mercado, Juan5; Kuan, Guillermina6; Gordon, Aubree7; Balmaseda, Angel5; Harris, Eva1 | |
2017-11-17 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6365页码:929-932 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Nicaragua |
英文摘要 | For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to enhance viral replication in vitro and severe disease in animal models. Although suspected, such antibody-dependent enhancement of severe disease has not been shown to occur in humans. Using multiple statistical approaches to study a long-term pediatric cohort in Nicaragua, we show that risk of severe dengue disease is highest within a narrow range of preexisting anti-DENV antibody titers. By contrast, we observe protection from all symptomatic dengue disease at high antibody titers. Thus, immune correlates of severe dengue must be evaluated separately from correlates of protection against symptomatic disease. These results have implications for studies of dengue pathogenesis and for vaccine development, because enhancement, not just lack of protection, is of concern. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000415293000048 |
WOS关键词 | MATERNAL ANTIBODY ; VIRUS ; PROTECTION ; COHORT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197350 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif Berkeley, Sch Publ Hlth, Div Infect Dis & Vaccinol, Berkeley, CA 94720 USA; 2.Sustainable Sci Inst, Managua, Nicaragua; 3.Univ Washington, Dept Biostat, Seattle, WA 98195 USA; 4.Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1124 Columbia St, Seattle, WA 98104 USA; 5.Minist Hlth, Lab Nacl Virol, Ctr Nacl Diagnost & Referencia, Managua, Nicaragua; 6.Minist Hlth, Ctr Salud Socrates Flores Vivas, Managua, Nicaragua; 7.Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA |
推荐引用方式 GB/T 7714 | Katzelnick, Leah C.,Gresh, Lionel,Halloran, M. Elizabeth,et al. Antibody-dependent enhancement of severe dengue disease in humans[J]. SCIENCE,2017,358(6365):929-932. |
APA | Katzelnick, Leah C..,Gresh, Lionel.,Halloran, M. Elizabeth.,Carlos Mercado, Juan.,Kuan, Guillermina.,...&Harris, Eva.(2017).Antibody-dependent enhancement of severe dengue disease in humans.SCIENCE,358(6365),929-932. |
MLA | Katzelnick, Leah C.,et al."Antibody-dependent enhancement of severe dengue disease in humans".SCIENCE 358.6365(2017):929-932. |
条目包含的文件 | 条目无相关文件。 |
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