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DOI | 10.1126/science.aao4815 |
Atomic model for the dimeric F-O region of mitochondrial ATP synthase | |
Guo, Hui1,2; Bueler, Stephanie A.1; Rubinstein, John L.1,2,3 | |
2017-11-17 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6365页码:936-940 |
文章类型 | Article |
语种 | 英语 |
国家 | Canada |
英文摘要 | Mitochondrial adenosine triphosphate (ATP) synthase produces the majority of ATP in eukaryotic cells, and its dimerization is necessary to create the inner membrane folds, or cristae, characteristic of mitochondria. Proton translocation through the membrane-embedded F-O region turns the rotor that drives ATP synthesis in the soluble F-1 region. Although crystal structures of the F-1 region have illustrated how this rotation leads to ATP synthesis, understanding how proton translocation produces the rotation has been impeded by the lack of an experimental atomic model for the F-O region. Using cryo-electron microscopy, we determined the structure of the dimeric F-O complex from Saccharomyces cerevisiae at a resolution of 3.6 angstroms. The structure clarifies how the protons travel through the complex, how the complex dimerizes, and how the dimers bend the membrane to produce cristae. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000415293000050 |
WOS关键词 | SUBUNIT-G ; PROTON TRANSLOCATION ; CRYO-EM ; RING |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197338 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Hosp Sick Children, Res Inst, Toronto, ON M5G 0A4, Canada; 2.Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada; 3.Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada |
推荐引用方式 GB/T 7714 | Guo, Hui,Bueler, Stephanie A.,Rubinstein, John L.. Atomic model for the dimeric F-O region of mitochondrial ATP synthase[J]. SCIENCE,2017,358(6365):936-940. |
APA | Guo, Hui,Bueler, Stephanie A.,&Rubinstein, John L..(2017).Atomic model for the dimeric F-O region of mitochondrial ATP synthase.SCIENCE,358(6365),936-940. |
MLA | Guo, Hui,et al."Atomic model for the dimeric F-O region of mitochondrial ATP synthase".SCIENCE 358.6365(2017):936-940. |
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