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DOI | 10.1126/science.aan8311 |
Calibrated mitotic oscillator drives motile ciliogenesis | |
Al Jord, Adel1; 39;Aout, Raphael Servignat2 | |
2017-11-10 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6364页码:803-806 |
文章类型 | Article |
语种 | 英语 |
国家 | France |
英文摘要 | Cell division and differentiation depend on massive and rapid organelle remodeling. The mitotic oscillator, centered on the cyclin-dependent kinase 1-anaphase-promoting complex/cyclosome (CDK1-APC/C) axis, spatiotemporally coordinates this reorganization in dividing cells. Here we discovered that nondividing cells could also implement this mitotic clocklike regulatory circuit to orchestrate subcellular reorganization associated with differentiation. We probed centriole amplification in differentiating mouse-brain multiciliated cells. These postmitotic progenitors fine-tuned mitotic oscillator activity to drive the orderly progression of centriole production, maturation, and motile ciliation while avoiding the mitosis commitment threshold. Insufficient CDK1 activity hindered differentiation, whereas excessive activity accelerated differentiation yet drove postmitotic progenitors into mitosis. Thus, postmitotic cells can redeploy and calibrate the mitotic oscillator to uncouple cytoplasmic from nuclear dynamics for organelle remodeling associated with differentiation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000414847100048 |
WOS关键词 | CENTROSOME AMPLIFICATION ; HUMAN-CELLS ; ACTIVATION ; PHOSPHORYLATION ; APC/C ; CYCLE ; DUPLICATION ; MECHANISM ; NUCLEAR ; MITOSIS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197290 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.PSL Res Univ, Ecole Normale Super IBENS, Inst Biol, F-75005 Paris, France; 2.CNRS, UMR 8197, F-75005 Paris, France; 3.INSERM, U1024, F-75005 Paris, France; 4.UPMC Paris 06, Sorbonne Univ, INSERM, CRSA, F-75012 Paris, France |
推荐引用方式 GB/T 7714 | Al Jord, Adel,39;Aout, Raphael Servignat. Calibrated mitotic oscillator drives motile ciliogenesis[J]. SCIENCE,2017,358(6364):803-806. |
APA | Al Jord, Adel,&39;Aout, Raphael Servignat.(2017).Calibrated mitotic oscillator drives motile ciliogenesis.SCIENCE,358(6364),803-806. |
MLA | Al Jord, Adel,et al."Calibrated mitotic oscillator drives motile ciliogenesis".SCIENCE 358.6364(2017):803-806. |
条目包含的文件 | 条目无相关文件。 |
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