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DOI | 10.1126/science.aan6009 |
ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in mammalian neurons | |
Hirabayahi, Yusuke1,2,3,4; Kwon, Seok-Kyu1,2,3; Paek, Hunki1,2,3; Pernice, Wolfgang M.5; Paul, Maela A.1,2,3; Lee, Jnoh1,2,3; Erfani, Parsa1,2,3; Raczkowski, Ashleigh7; Petrey, Donald S.8,9; Pon, Liza A.5,6; Polleux, Franck1,2,3 | |
2017-11-03 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6363页码:623-629 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Japan |
英文摘要 | Interfaces between organelles are emerging as critical platforms for many biological responses in eukaryotic cells. In yeast, the ERMES complex is an endoplasmic reticulum (ER)-mitochondria tether composed of four proteins, three of which contain a SMP (synaptotagmin-like mitochondrial-lipid binding protein) domain. No functional ortholog for any ERMES protein has been identified in metazoans. Here, we identified PDZD8 as an ER protein present at ER-mitochondria contacts. The SMP domain of PDZD8 is functionally orthologous to the SMP domain found in yeast Mmm1. PDZD8 was necessary for the formation of ER-mitochondria contacts in mammalian cells. In neurons, PDZD8 was required for calcium ion (Ca2+) uptake by mitochondria after synaptically induced Ca2+-release from ER and thereby regulated cytoplasmic Ca2+ dynamics. Thus, PDZD8 represents a critical ER-mitochondria tethering protein in metazoans. We suggest that ER-mitochondria coupling is involved in the regulation of dendritic Ca2+ dynamics in mammalian neurons. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000414240500031 |
WOS关键词 | LIPID-BINDING PROTEINS ; ENDOPLASMIC-RETICULUM ; MITOFUSIN 2 ; TULIP SUPERFAMILY ; CALCIUM-RELEASE ; SMP DOMAINS ; CONTACTS ; PLASTICITY ; STORES ; ORGANIZATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197245 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Columbia Univ, Dept Neurosci, Med Ctr, New York, NY 10027 USA; 2.Columbia Univ, Mortimer B Zuckerman Mind Brain Behav Inst, New York, NY 10027 USA; 3.Columbia Univ, Kavli Inst Brain Sci, New York, NY 10027 USA; 4.Japan Sci & Technol Agcy JST, Precursory Res Embryon Sci & Technol PRESTO, Tokyo, Japan; 5.Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA; 6.Columbia Univ, Inst Human Nutr, New York, NY 10032 USA; 7.NYSBC, Simons Electron Microscopy Ctr, New York, NY 10027 USA; 8.Columbia Univ, Dept Syst Biol, Ctr Computat Biol & Bioinformat, New York, NY 10032 USA; 9.Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA |
推荐引用方式 GB/T 7714 | Hirabayahi, Yusuke,Kwon, Seok-Kyu,Paek, Hunki,et al. ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in mammalian neurons[J]. SCIENCE,2017,358(6363):623-629. |
APA | Hirabayahi, Yusuke.,Kwon, Seok-Kyu.,Paek, Hunki.,Pernice, Wolfgang M..,Paul, Maela A..,...&Polleux, Franck.(2017).ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in mammalian neurons.SCIENCE,358(6363),623-629. |
MLA | Hirabayahi, Yusuke,et al."ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in mammalian neurons".SCIENCE 358.6363(2017):623-629. |
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