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DOI | 10.1126/science.aan6516 |
The condensin complex is a mechanochemical motor that translocates along DNA | |
Terakawa, Tsuyoshi1; Bisht, Shveta2; Eeftens, Jorine M.3; Dekker, Cees3; Haering, Christian H.2; Greene, Eric C.1 | |
2017-11-03 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6363页码:672-676 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Germany; Netherlands |
英文摘要 | Condensin plays crucial roles in chromosome organization and compaction, but the mechanistic basis for its functions remains obscure. We used single-molecule imaging to demonstrate that Saccharomyces cerevisiae condensin is a molecular motor capable of adenosine triphosphate hydrolysis-dependent translocation along double-stranded DNA. Condensin's translocation activity is rapid and highly processive, with individual complexes traveling an average distance of >= 10 kilobases at a velocity of similar to 60 base pairs per second. Our results suggest that condensin may take steps comparable in length to its similar to 50-nanometer coiled-coil subunits, indicative of a translocation mechanism that is distinct from any reported for a DNA motor protein. The finding that condensin is a mechanochemical motor has important implications for understanding the mechanisms of chromosome organization and condensation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000414240500043 |
WOS关键词 | SMC FAMILY ; ORGANIZATION ; ARCHITECTURE ; CHROMOSOMES ; COMPACTION ; MECHANISM ; BINDING ; MITOSIS ; COHESIN ; GENOME |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197244 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA; 2.EMBL, Cell Biol & Biophys Unit, Struct & Computat Unit, Heidelberg, Germany; 3.Delft Univ Technol, Dept Bionanosci, Kavi Inst Nanosci, Delft, Netherlands |
推荐引用方式 GB/T 7714 | Terakawa, Tsuyoshi,Bisht, Shveta,Eeftens, Jorine M.,et al. The condensin complex is a mechanochemical motor that translocates along DNA[J]. SCIENCE,2017,358(6363):672-676. |
APA | Terakawa, Tsuyoshi,Bisht, Shveta,Eeftens, Jorine M.,Dekker, Cees,Haering, Christian H.,&Greene, Eric C..(2017).The condensin complex is a mechanochemical motor that translocates along DNA.SCIENCE,358(6363),672-676. |
MLA | Terakawa, Tsuyoshi,et al."The condensin complex is a mechanochemical motor that translocates along DNA".SCIENCE 358.6363(2017):672-676. |
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