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DOI | 10.1126/science.aam8659 |
N-epsilon-Fatty acylation of Rho GTPases by a MARTX toxin effector | |
Zhou, Yan1,2; Huang, Chunfeng1,2; Yin, Li1,2; Wan, Muyang1,2; Wang, Xiaofei1,2; Li, Lin3; Liu, Yanhua4; Wang, Zhao1,2; Fu, Panhan1,2; Zhang, Ni1,2; Chen, She3; Liu, Xiaoyun4; Shao, Feng3; Zhu, Yongqun1,2 | |
2017-10-27 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6362页码:528-530 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | The multifunctional autoprocessing repeats-in-toxin (MARTX) toxins are a family of large toxins that are extensively distributed in bacterial pathogens. MARTX toxins are autocatalytically cleaved to multiple effector domains, which are released into host cells to modulate the host signaling pathways. The Rho guanosine triphosphatase (GTPase) inactivation domain (RID), a conserved effector domain of MARTX toxins, is implicated in cell rounding by disrupting the host actin cytoskeleton. We found that the RID is an N-epsilon-fatty acyltransferase that covalently modifies the lysine residues in the C-terminal polybasic region of Rho GTPases. The resulting fatty acylation inhibited Rho GTPases and disrupted Rho GTPase-mediated signaling in the host. Thus, RID can mediate the lysine N-epsilon-fatty acylation of mammalian proteins and represents a family of toxins that harbor N-fatty acyltransferase activities in bacterial pathogens. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413757500046 |
WOS关键词 | VIBRIO-CHOLERAE ; IDENTIFICATION ; INACTIVATION ; PRECURSOR ; PROTEINS ; DOMAIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197206 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Zhejiang Univ, Life Sci Inst, Hangzhou 310058, Zhejiang, Peoples R China; 2.Zhejiang Univ, Innovat Ctr Cell Signaling Network, Hangzhou 310058, Zhejiang, Peoples R China; 3.Natl Inst Biol Sci, Beijing 102206, Peoples R China; 4.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China |
推荐引用方式 GB/T 7714 | Zhou, Yan,Huang, Chunfeng,Yin, Li,et al. N-epsilon-Fatty acylation of Rho GTPases by a MARTX toxin effector[J]. SCIENCE,2017,358(6362):528-530. |
APA | Zhou, Yan.,Huang, Chunfeng.,Yin, Li.,Wan, Muyang.,Wang, Xiaofei.,...&Zhu, Yongqun.(2017).N-epsilon-Fatty acylation of Rho GTPases by a MARTX toxin effector.SCIENCE,358(6362),528-530. |
MLA | Zhou, Yan,et al."N-epsilon-Fatty acylation of Rho GTPases by a MARTX toxin effector".SCIENCE 358.6362(2017):528-530. |
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