Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aan1478 |
Plasmepsins IX and X are essential and draggable mediators of malaria parasite egress and invasion | |
Nasamu, Armiyaw S.1,2; Glushakova, Svetlana3; Russo, Ilaria4; Vaupel, Barbara1,2; Oksman, Anna1,2; Kim, Arthur S.1,5; Fremont, Daved H.5; Tolia, Niraj2; Beck, Josh R.1,2; Meyers, Marvin J.6; Niles, Jacquin C.7; Zimmerberg, Joshua3; Goldberg, Daniel E.1,2 | |
2017-10-27 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6362页码:518-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; England |
英文摘要 | Proteases of the malaria parasite Plasmodium falciparum have long been investigated as drug targets. The P. falciparum genome encodes 10 aspartic proteases called plasmepsins, which are involved in diverse cellular processes. Most have been studied extensively but the functions of plasmepsins IX and X (PMIX and PMX) were unknown. Here we show that PMIX is essential for erythrocyte invasion, acting on rhoptry secretory organelle biogenesis. In contrast, PMX is essential for both egress and invasion, controlling maturation of the subtilisin-like serine protease SUB1 in exoneme secretory vesicles. We have identified compounds with potent antimalarial activity targeting PMX, including a compound known to have oral efficacy in a mouse model of malaria. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413757500044 |
WOS关键词 | SUBTILISIN-LIKE PROTEASE-1 ; PLASMODIUM-FALCIPARUM ; SERINE-PROTEASE ; CELL INVASION ; HOST-CELL ; PROTEINS ; IDENTIFICATION ; ERYTHROCYTES ; EXPRESSION ; INHIBITORS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197204 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Washington Univ, Sch Med, Dept Med, Div Infect Dis, St Louis, MO 63110 USA; 2.Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA; 3.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Integrat Biophys, NIH, Bethesda, MD 20892 USA; 4.Univ Manchester, Sch Biol Sci, Div Infect Immun & Resp Med, Fac Biol Med & Hlth, Manchester, Lancs, England; 5.Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA; 6.St Louis Univ, Sch Med, Ctr World Hlth & Med, St Louis, MO 63104 USA; 7.MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA |
推荐引用方式 GB/T 7714 | Nasamu, Armiyaw S.,Glushakova, Svetlana,Russo, Ilaria,et al. Plasmepsins IX and X are essential and draggable mediators of malaria parasite egress and invasion[J]. SCIENCE,2017,358(6362):518-+. |
APA | Nasamu, Armiyaw S..,Glushakova, Svetlana.,Russo, Ilaria.,Vaupel, Barbara.,Oksman, Anna.,...&Goldberg, Daniel E..(2017).Plasmepsins IX and X are essential and draggable mediators of malaria parasite egress and invasion.SCIENCE,358(6362),518-+. |
MLA | Nasamu, Armiyaw S.,et al."Plasmepsins IX and X are essential and draggable mediators of malaria parasite egress and invasion".SCIENCE 358.6362(2017):518-+. |
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