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DOI | 10.1126/science.aan5353 |
Second messenger-mediated tactile response by a bacterial rotary motor | |
Hug, Isabelle1; Deshpande, Siddharth2,3; Sprecher, Kathrin S.1; Pfohl, Thomas2,4; Jenal, Urs1 | |
2017-10-27 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6362页码:531-534 |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; Netherlands; Germany |
英文摘要 | When bacteria encounter surfaces, they respond with surface colonization and virulence induction. The mechanisms of bacterial mechanosensation and downstream signaling remain poorly understood. Here, we describe a tactile sensing cascade in Caulobacter crescentus in which the flagellar motor acts as sensor. Surface-induced motor interference stimulated the production of the second messenger cyclic diguanylate by the motor-associated diguanylate cyclase DgcB. This led to the allosteric activation of the glycosyltransferase HfsJ to promote rapid synthesis of a polysaccharide adhesin and surface anchoring. Although the membrane-embedded motor unit was essential for surface sensing, mutants that lack external flagellar structures were hypersensitive to mechanical stimuli. Thus, the bacterial flagellar motor acts as a tetherless sensor reminiscent of mechanosensitive channels. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413757500047 |
WOS关键词 | FLAGELLAR MOTOR ; PSEUDOMONAS-AERUGINOSA ; CELL-DIFFERENTIATION ; SURFACE ATTACHMENT ; VIRULENCE ; NETWORKS ; BIOFILMS ; HOLDFAST |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197202 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Basel, Biozentrum, Klingelbergstr 50-70, CH-4056 Basel, Switzerland; 2.Univ Basel, Dept Chem, Klingelbergstr 80, CH-4056 Basel, Switzerland; 3.Delft Univ Technol, Dept Bionanosci, Van der Maasweg 9, NL-2629 HZ Delft, Netherlands; 4.Univ Freiburg, Inst Phys, Hermann Herder Str 3, D-79104 Freiburg, Germany |
推荐引用方式 GB/T 7714 | Hug, Isabelle,Deshpande, Siddharth,Sprecher, Kathrin S.,et al. Second messenger-mediated tactile response by a bacterial rotary motor[J]. SCIENCE,2017,358(6362):531-534. |
APA | Hug, Isabelle,Deshpande, Siddharth,Sprecher, Kathrin S.,Pfohl, Thomas,&Jenal, Urs.(2017).Second messenger-mediated tactile response by a bacterial rotary motor.SCIENCE,358(6362),531-534. |
MLA | Hug, Isabelle,et al."Second messenger-mediated tactile response by a bacterial rotary motor".SCIENCE 358.6362(2017):531-534. |
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