Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aah5072 |
Adrenergic nerves activate an angio-metabolic switch in prostate cancer | |
Zahalka, Ali H.1,2; Arnal-Estape, Anna1,2,5; Maryanovich, Maria1,2; Nakahara, Fumio1,2; Cruz, Cristian D.1,2; Finley, Lydia W. S.3; Frenette, Paul S.1,2,4 | |
2017-10-20 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6361页码:321-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Nerves closely associate with blood vessels and help to pattern the vasculature during development. Recent work suggests that newly formed nerve fibers may regulate the tumor microenvironment, but their exact functions are unclear. Studying mouse models of prostate cancer, we show that endothelial beta-adrenergic receptor signaling via adrenergic nerve-derived noradrenaline in the prostate stroma is critical for activation of an angiogenic switch that fuels exponential tumor growth. Mechanistically, this occurs through alteration of endothelial cell metabolism. Endothelial cells typically rely on aerobic glycolysis for angiogenesis. We found that the loss of endothelial Adrb2, the gene encoding the beta(2)-adrenergic receptor, leads to inhibition of angiogenesis through enhancement of endothelial oxidative phosphorylation. Codeletion of Adrb2 and Cox10, a gene encoding a cytochrome IV oxidase assembly factor, prevented the metabolic shift induced by Adrb2 deletion and rescued prostate cancer progression. This cross-talk between nerves and endothelial metabolism could potentially be targeted as an anticancer therapy. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413251000032 |
WOS关键词 | ANGIOGENESIS ; CELL ; MODEL ; MITOCHONDRIA ; INFLAMMATION ; PROGRESSION ; INHIBITION ; GLYCOLYSIS ; INDUCTION ; PHENOTYPE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197159 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Albert Einstein Coll Med, Ruth L & David S Gottesman Inst Stem Cell & Regen, Bronx, NY 10461 USA; 2.Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10461 USA; 3.Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10065 USA; 4.Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA; 5.Yale Sch Med, Dept Pathol, New Haven, CT 06520 USA |
推荐引用方式 GB/T 7714 | Zahalka, Ali H.,Arnal-Estape, Anna,Maryanovich, Maria,et al. Adrenergic nerves activate an angio-metabolic switch in prostate cancer[J]. SCIENCE,2017,358(6361):321-+. |
APA | Zahalka, Ali H..,Arnal-Estape, Anna.,Maryanovich, Maria.,Nakahara, Fumio.,Cruz, Cristian D..,...&Frenette, Paul S..(2017).Adrenergic nerves activate an angio-metabolic switch in prostate cancer.SCIENCE,358(6361),321-+. |
MLA | Zahalka, Ali H.,et al."Adrenergic nerves activate an angio-metabolic switch in prostate cancer".SCIENCE 358.6361(2017):321-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论