Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV

doi:10.1126/science.aan7969

GSTDTAP > 地球科学

DOI	10.1126/science.aan7969
	Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV
	Wender, Paul A.1,2; Hardman, Clayton T.1; Ho, Stephen 1; Jeffreys, Matthew S.1; Maclaren, Jana K.3; Quiroz, Ryan V.1; Ryckbosch, Steven M.1; Shimizu, Akira J.1; Sloane, Jack L.1; Stevens, Matthew C.1
	2017-10-13
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2017
卷号	358 期号:6360 页码:218-222
文章类型	Article
语种	英语
国家	USA
英文摘要	Bryostatin 1 is an exceedingly scarce marine-derived natural product that is in clinical development directed at HIV/AIDS eradication, cancer immunotherapy, and the treatment of Alzheimer's disease. Despite this unique portfolio of indications, its availability has been limited and variable, thus impeding research and clinical studies. Here, we report a total synthesis of bryostatin 1 that proceeds in 29 total steps (19 in the longest linear sequence, >80% average yield per step), collectively produces grams of material, and can be scaled to meet clinical needs (similar to 20 grams per year). This practical solution to the bryostatin supply problem also opens broad, facile, and efficient access to derivatives and potentially superior analogs.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000412841500047
WOS关键词	PROTEIN-KINASE-C ; LYMPHOCYTIC-LEUKEMIA CELLS ; ALZHEIMERS-DISEASE ; VIRUS REACTIVATION ; PYRAN ANNULATION ; BUGULA-NERITINA ; PKC-ALPHA ; ALDEHYDES ; KETONES ; ACCESS
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
URL	查看原文
引用统计	被引频次：75[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/197090
专题	地球科学资源环境科学气候变化
作者单位	1.Stanford Univ, Dept Chem, Stanford, CA 94305 USA; 2.Stanford Univ, Dept Chem & Syst Biol, Stanford, CA 94305 USA; 3.Stanford Univ, Stanford Nano Shared Facil, Stanford, CA 94305 USA
推荐引用方式 GB/T 7714	Wender, Paul A.,Hardman, Clayton T.,Ho, Stephen,et al. Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV[J]. SCIENCE,2017,358(6360):218-222.
APA	Wender, Paul A..,Hardman, Clayton T..,Ho, Stephen.,Jeffreys, Matthew S..,Maclaren, Jana K..,...&Stevens, Matthew C..(2017).Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV.SCIENCE,358(6360),218-222.
MLA	Wender, Paul A.,et al."Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV".SCIENCE 358.6360(2017):218-222.