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DOI | 10.1126/science.aal4671 |
Mitotic transcription and waves of gene reactivation during mitotic exit | |
Palozola, Katherine C.1,2; Donahue, Greg2; Liu, Hong3,4; Grant, Gregory R.5; Becker, Justin S.1,2; Cote, Allison6; Yu, Hongtao7; Raj, Arjun6; Zaret, Kenneth S.1,2 | |
2017-10-06 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6359页码:119-122 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Although the genome is generally thought to be transcriptionally silent during mitosis, technical limitations have prevented sensitive mapping of transcription during mitosis and mitotic exit. Thus, the means by which the interphase expression pattern is transduced to daughter cells have been unclear. We used 5-ethynyluridine to pulse-label transcripts during mitosis and mitotic exit and found that many genes exhibit transcription during mitosis, as confirmed with fluorescein isothiocyanate-uridine 5'-triphosphate labeling, RNA fluorescence in situ hybridization, and quantitative reverse transcription polymerase chain reaction. The first round of transcription immediately after mitosis primarily activates genes involved in the growth and rebuilding of daughter cells, rather than cell type-specific functions. We propose that the cell's transcription pattern is largely retained at a low level through mitosis, whereas the amplitude of transcription observed in interphase is reestablished during mitotic exit. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000412359600066 |
WOS关键词 | INTEGRATIVE ANALYSIS ; CELL-CYCLE ; RNA ; BOOKMARKING ; MITOSIS ; CHROMOSOME ; MARKS ; DIFFERENTIATION ; PLURIPOTENCY ; REPRESSION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197029 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Penn, Inst Regenerat Med, Perelman Sch Med, Philadelphia, PA 19104 USA; 2.Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA; 3.Tulane Univ, Dept Biochem & Mol Biol, New Orleans, LA 70112 USA; 4.Tulane Univ, Tulane Ctr Aging, New Orleans, LA 70112 USA; 5.Univ Penn, Inst Translat Med & Therapeut, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA; 6.Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA; 7.Univ Texas Southwestern Med Ctr Dallas, Dept Pharmacol, Howard Hughes Med Inst, Dallas, TX 75390 USA |
推荐引用方式 GB/T 7714 | Palozola, Katherine C.,Donahue, Greg,Liu, Hong,et al. Mitotic transcription and waves of gene reactivation during mitotic exit[J]. SCIENCE,2017,358(6359):119-122. |
APA | Palozola, Katherine C..,Donahue, Greg.,Liu, Hong.,Grant, Gregory R..,Becker, Justin S..,...&Zaret, Kenneth S..(2017).Mitotic transcription and waves of gene reactivation during mitotic exit.SCIENCE,358(6359),119-122. |
MLA | Palozola, Katherine C.,et al."Mitotic transcription and waves of gene reactivation during mitotic exit".SCIENCE 358.6359(2017):119-122. |
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