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DOI | 10.1126/science.aan1221 |
Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia | |
Tinnermann, A.1; Geuter, S.1,2; Sprenger, C.1,3; Finsterbusch, J.1; Buechel, C.1 | |
2017-10-06 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6359页码:105-108 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; USA; England |
英文摘要 | Value information about a drug, such as the price tag, can strongly affect its therapeutic effect. We discovered that value information influences adverse treatment outcomes in humans even in the absence of an active substance. Labeling an inert treatment as expensive medication led to stronger nocebo hyperalgesia than labeling it as cheap medication. This effect was mediated by neural interactions between cortex, brainstem, and spinal cord. In particular, activity in the prefrontal cortex mediated the effect of value on nocebo hyperalgesia. Value furthermore modulated coupling between prefrontal areas, brainstem, and spinal cord, which might represent a flexible mechanism through which higher-cognitive representations, such as value, can modulate early pain processing. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000412359600062 |
WOS关键词 | PERIAQUEDUCTAL GRAY ; PLACEBO ANALGESIA ; PAIN PERCEPTION ; FUNCTIONAL CONNECTIVITY ; RESPONSES ; FMRI ; REPRESENTATION ; EXPECTATION ; ACTIVATION ; MECHANISMS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197025 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Med Ctr Hamburg Eppendorf, Inst Syst Neurosci, D-20246 Hamburg, Germany; 2.Univ Colorado, Inst Cognit Sci, Boulder, CO 80309 USA; 3.Univ Cambridge, Dept Engn, Computat & Biol Learning Lab, Cambridge CB2 1PZ, England |
推荐引用方式 GB/T 7714 | Tinnermann, A.,Geuter, S.,Sprenger, C.,et al. Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia[J]. SCIENCE,2017,358(6359):105-108. |
APA | Tinnermann, A.,Geuter, S.,Sprenger, C.,Finsterbusch, J.,&Buechel, C..(2017).Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia.SCIENCE,358(6359),105-108. |
MLA | Tinnermann, A.,et al."Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia".SCIENCE 358.6359(2017):105-108. |
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