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DOI | 10.1126/science.aan6826 |
Single-cell epigenomics: Recording the past and predicting the future | |
Kelsey, Gavin1,2; Stegle, Oliver3,4; Reik, Wolf1,2,5 | |
2017-10-06 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6359页码:69-75 |
文章类型 | Review |
语种 | 英语 |
国家 | England; Germany |
英文摘要 | Single-cell multi-omics has recently emerged as a powerful technology by which different layers of genomic output-and hence cell identity and function-can be recorded simultaneously. Integrating various components of the epigenome into multi-omics measurements allows for studying cellular heterogeneity at different time scales and for discovering new layers of molecular connectivity between the genome and its functional output. Measurements that are increasingly available range from those that identify transcription factor occupancy and initiation of transcription to long-lasting and heritable epigenetic marks such as DNA methylation. Together with techniques in which cell lineage is recorded, this multilayered information will provide insights into a cell's past history and its future potential. This will allow new levels of understanding of cell fate decisions, identity, and function in normal development, physiology, and disease. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000412359600055 |
WOS关键词 | EMBRYONIC STEM-CELLS ; DNA METHYLATION ; HI-C ; CHROMATIN ACCESSIBILITY ; EPIGENETIC HETEROGENEITY ; REGULATORY ELEMENTS ; GENOME ; MOUSE ; METHYLOME ; STATE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197022 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Babraham Inst, Epigenet Programme, Cambridge CB22 3AT, England; 2.Univ Cambridge, Ctr Trophoblast Res, Cambridge CB2 3EG, England; 3.European Bioinformat Inst, European Mol Biol Lab, Wellcome Genome Campus, Cambridge CB10 1SD, England; 4.European Mol Biol Lab, Genome Biol Unit, D-69117 Heidelberg, Germany; 5.Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England |
推荐引用方式 GB/T 7714 | Kelsey, Gavin,Stegle, Oliver,Reik, Wolf. Single-cell epigenomics: Recording the past and predicting the future[J]. SCIENCE,2017,358(6359):69-75. |
APA | Kelsey, Gavin,Stegle, Oliver,&Reik, Wolf.(2017).Single-cell epigenomics: Recording the past and predicting the future.SCIENCE,358(6359),69-75. |
MLA | Kelsey, Gavin,et al."Single-cell epigenomics: Recording the past and predicting the future".SCIENCE 358.6359(2017):69-75. |
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