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DOI | 10.1126/science.aan6827 |
The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing | |
Lein, Ed1; Borm, Lars E.2,3; Linnarsson, Sten2,3 | |
2017-10-06 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6359页码:64-+ |
文章类型 | Review |
语种 | 英语 |
国家 | USA; Sweden |
英文摘要 | The stereotyped spatial architecture of the brain is both beautiful and fundamentally related to its function, extending from gross morphology to individual neuron types, where soma position, dendritic architecture, and axonal projections determine their roles in functional circuitry. Our understanding of the cell types that make up the brain is rapidly accelerating, driven in particular by recent advances in single-cell transcriptomics. However, understanding brain function, development, and disease will require linking molecular cell types to morphological, physiological, and behavioral correlates. Emerging spatially resolved transcriptomic methods promise to fill this gap by localizing molecularly defined cell types in tissues, with simultaneous detection of morphology, activity, or connectivity. Here, we review the requirements for spatial transcriptomic methods toward these goals, consider the challenges ahead, and describe promising applications. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000412359600054 |
WOS关键词 | IN-SITU HYBRIDIZATION ; HUMAN BRAIN TRANSCRIPTOME ; RNA-SEQ ; GENE-EXPRESSION ; EXPANSION MICROSCOPY ; NEURONAL SUBTYPES ; CHAIN-REACTION ; INTACT-TISSUE ; SINGLE CELLS ; MOUSE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197021 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Allen Inst Brain Sci, Seattle, WA 98109 USA; 2.Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, S-17177 Stockholm, Sweden; 3.Sci Life Lab, S-17121 Solna, Sweden |
推荐引用方式 GB/T 7714 | Lein, Ed,Borm, Lars E.,Linnarsson, Sten. The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing[J]. SCIENCE,2017,358(6359):64-+. |
APA | Lein, Ed,Borm, Lars E.,&Linnarsson, Sten.(2017).The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing.SCIENCE,358(6359),64-+. |
MLA | Lein, Ed,et al."The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing".SCIENCE 358.6359(2017):64-+. |
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