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DOI | 10.1126/science.aan6828 |
Single-cell transcriptomics to explore the immune system in health and disease | |
Stubbington, Michael J. T.1; Rozenblatt-Rosen, Orit2; Regev, Aviv2,3; Teichmann, Sarah A.1,4 | |
2017-10-06 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6359页码:58-63 |
文章类型 | Review |
语种 | 英语 |
国家 | England; USA |
英文摘要 | The immune system varies in cell types, states, and locations. The complex networks, interactions, and responses of immune cells produce diverse cellular ecosystems composed of multiple cell types, accompanied by genetic diversity in antigen receptors. Within this ecosystem, innate and adaptive immune cells maintain and protect tissue function, integrity, and homeostasis upon changes in functional demands and diverse insults. Characterizing this inherent complexity requires studies at single-cell resolution. Recent advances such as massively parallel single-cell RNA sequencing and sophisticated computational methods are catalyzing a revolution in our understanding of immunology. Here we provide an overview of the state of single-cell genomics methods and an outlook on the use of single-cell techniques to decipher the adaptive and innate components of immunity. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000412359600053 |
WOS关键词 | RNA-SEQUENCING REVEALS ; INNATE LYMPHOID-CELLS ; HETEROGENEITY ; RECEPTOR ; EXPRESSION ; BIOLOGY ; LINKING ; EPITOPE ; DIFFERENTIATION ; VARIABILITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197020 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Wellcome Trust Sanger Inst, Wellcome Genome Campus, Cambridge CB10 1SA, England; 2.Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA; 3.MIT, Dept Biol, Howard Hughes Med Inst, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 4.Cavendish Lab, Theory Condensed Matter, 19 JJ Thomson Ave, Cambridge CB3 0HE, England |
推荐引用方式 GB/T 7714 | Stubbington, Michael J. T.,Rozenblatt-Rosen, Orit,Regev, Aviv,et al. Single-cell transcriptomics to explore the immune system in health and disease[J]. SCIENCE,2017,358(6359):58-63. |
APA | Stubbington, Michael J. T.,Rozenblatt-Rosen, Orit,Regev, Aviv,&Teichmann, Sarah A..(2017).Single-cell transcriptomics to explore the immune system in health and disease.SCIENCE,358(6359),58-63. |
MLA | Stubbington, Michael J. T.,et al."Single-cell transcriptomics to explore the immune system in health and disease".SCIENCE 358.6359(2017):58-63. |
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