Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aam6468 |
ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links | |
Schellenberg, Matthew J.1; Ariel Lieberman, Jenna2; Herrero-Ruiz, Andres2; Butler, Logan R.1; Williams, Jason G.3; Munoz-Cabello, Ana M.2,4; Mueller, Geoffrey A.1; London, Robert E.1; Cortes-Ledesma, Felipe2; Williams, R. Scott1 | |
2017-09-29 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6358页码:1412-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Spain |
英文摘要 | Topoisomerase 2 (TOP2) DNA transactions proceed via formation of the TOP2 cleavage complex (TOP2cc), a covalent enzyme-DNA reaction intermediate that is vulnerable to trapping by potent anticancer TOP2 drugs. How genotoxic TOP2 DNA-protein cross-links are resolved is unclear. We found that the SUMO (small ubiquitin-related modifier) ligase ZATT (ZNF451) is a multifunctional DNA repair factor that controls cellular responses to TOP2 damage. ZATT binding to TOP2cc facilitates a proteasome-independent tyrosyl-DNA phosphodiesterase 2 (TDP2) hydrolase activity on stalled TOP2cc. The ZATT SUMO ligase activity further promotes TDP2 interactions with SUMOylated TOP2, regulating efficient TDP2 recruitment through a "split-SIM" SUMO2 engagement platform. These findings uncover a ZATT-TDP2-catalyzed and SUMO2-modulated pathway for direct resolution of TOP2cc. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000411880800050 |
WOS关键词 | STRUCTURAL BASIS ; COVALENT COMPLEXES ; PHOSPHODIESTERASE ; SUMO ; TDP2 ; REPAIR ; INHIBITORS ; UBIQUITIN ; PATHWAY ; DAMAGE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196973 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.NIEHS, Genome Integr & Struct Biol Lab, POB 12233, Res Triangle Pk, NC 27709 USA; 2.Univ Pablo Olavide, Univ Sevilla, CSIC, Ctr Andaluz Biol Mol & Med Regenerativ CABIMER, Seville 41092, Spain; 3.NIEHS, Epigenet & Stem Cell Biol Lab, Res Triangle Pk, NC 27709 USA; 4.Univ Seville, Hosp Univ Virgen Rocio, Dept Fisiol Med & Biofis, Inst Biomed Sevilla IBiS,CSIC,CIBERNED, Seville 41013, Spain |
推荐引用方式 GB/T 7714 | Schellenberg, Matthew J.,Ariel Lieberman, Jenna,Herrero-Ruiz, Andres,et al. ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links[J]. SCIENCE,2017,357(6358):1412-+. |
APA | Schellenberg, Matthew J..,Ariel Lieberman, Jenna.,Herrero-Ruiz, Andres.,Butler, Logan R..,Williams, Jason G..,...&Williams, R. Scott.(2017).ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links.SCIENCE,357(6358),1412-+. |
MLA | Schellenberg, Matthew J.,et al."ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links".SCIENCE 357.6358(2017):1412-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论