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DOI | 10.1126/science.aan5478 |
Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria | |
Wang, Sibao1; Dos-Santos, Andre L. A.2,3; Huang, Wei2; Liu, Kun Connie2,4; Oshaghi, Mohammad Ali2,5; Wei, Ge1; Agre, Peter2; Jacobs-Lorena, Marcelo2 | |
2017-09-29 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6358页码:1399-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA; Brazil; Iran |
英文摘要 | The huge burden of malaria in developing countries urgently demands the development of novel approaches to fight this deadly disease. Although engineered symbiotic bacteria have been shown to render mosquitoes resistant to the parasite, the challenge remains to effectively introduce such bacteria into mosquito populations. We describe a Serratia bacterium strain (AS1) isolated from Anopheles ovaries that stably colonizes the mosquito midgut, female ovaries, and male accessory glands and spreads rapidly throughout mosquito populations. Serratia AS1 was genetically engineered for secretion of anti-Plasmodium effector proteins, and the recombinant strains inhibit development of Plasmodium falciparum in mosquitoes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000411880800047 |
WOS关键词 | ARTEMISININ RESISTANCE ; ANOPHELES-STEPHENSI ; MALARIA PARASITE ; VECTOR MOSQUITOS ; GENE DRIVE ; MIDGUT ; PARATRANSGENESIS ; TRANSMISSION ; INFECTION ; GAMBIAE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196969 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Key Lab Insect Dev & Evolutionary Biol, Shanghai 200032, Peoples R China; 2.Johns Hopkins Bloomberg Sch Publ Hlth, Malaria Res Inst, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA; 3.Univ Fed Rio de Janeiro, Inst Bioquim Med Leopoldo de Meis, BR-21941902 Rio De Janeiro, RJ, Brazil; 4.US FDA, Off Regulatory Affairs, Pacific Reg Lab Northwest, 22201 23rd Dr Southeast, Bothell, WA 98021 USA; 5.Univ Tehran Med Sci, Sch Publ Hlth, Dept Med Entomol & Vector Control, POB 14155-6446, Tehran, Iran |
推荐引用方式 GB/T 7714 | Wang, Sibao,Dos-Santos, Andre L. A.,Huang, Wei,et al. Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria[J]. SCIENCE,2017,357(6358):1399-+. |
APA | Wang, Sibao.,Dos-Santos, Andre L. A..,Huang, Wei.,Liu, Kun Connie.,Oshaghi, Mohammad Ali.,...&Jacobs-Lorena, Marcelo.(2017).Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria.SCIENCE,357(6358),1399-+. |
MLA | Wang, Sibao,et al."Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria".SCIENCE 357.6358(2017):1399-+. |
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