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DOI | 10.1126/science.aam8526 |
Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function | |
Piwecka, Monika1; Glazar, Petar1; Hernandez-Miranda, Luis R.2; Memczak, Sebastian1,3,4; Wolf, Susanne A.5; Rybak-Wolf, Agnieszka1; Filipchyk, Andrei1; Klironomos, Filippos1; Jara, Cledi Alicia Cerda1; Fenske, Pascal6; Trimbuch, Thorsten6; Zywitza, Vera1; Plass, Mireya1; Schreyer, Luisa1; Ayoub, Salah1; Kocks, Christine1; Kuhn, Ralf7,8; Rosenmund, Christian; Birchmeier, Carmen2; Rajewsky, Nikolaus1 | |
2017-09-22 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6357 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany |
英文摘要 | Hundreds of circular RNAs (circRNAs) are highly abundant in the mammalian brain, often with conserved expression. Here we show that the circRNA Cdr1as is massively bound by the microRNAs (miRNAs) miR-7 and miR-671 in human and mouse brains. When the Cdr1as locus was removed from the mouse genome, knockout animals displayed impaired sensorimotor gating-a deficit in the ability to filter out unnecessary information-which is associated with neuropsychiatric disorders. Electrophysiological recordings revealed dysfunctional synaptic transmission. Expression of miR-7 and miR-671 was specifically and posttranscriptionally misregulated in all brain regions analyzed. Expression of immediate early genes such as Fos, a direct miR-7 target, was enhanced in Cdr1as-deficient brains, providing a possible molecular link to the behavioral phenotype. Our data indicate an in vivo loss-of-function circRNA phenotype and suggest that interactions between Cdr1as and miRNAs are important for normal brain function. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000411337700036 |
WOS关键词 | PREPULSE INHIBITION ; EXON CIRCULARIZATION ; NEURONAL ENSEMBLES ; EXPRESSION ; STARTLE ; SCHIZOPHRENIA ; PLASTICITY ; MICRORNA-7 ; DISCOVERY ; EFFICIENT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196930 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Max Delbruck Ctr Mol Med, Berlin Inst Med Syst Biol, Lab Syst Biol Gene Regulatory Elements, Robert Rossle Str 10, Berlin, Germany; 2.Max Delbruck Ctr Mol Med, Lab Dev Biol & Signal Transduct, Robert Rossle Str 10, Berlin, Germany; 3.Charite Med Fac, Expt & Clin Res Ctr, Robert Rossle Str 10, Berlin, Germany; 4.Max Delbruck Ctr Mol Med, Robert Rossle Str 10, Berlin, Germany; 5.Max Delbruck Ctr Mol Med, Lab Cellular Neurosci, Robert Rossle Str 10, Berlin, Germany; 6.Charite, NeuroCure Cluster Excellence, Dept Neurophysiol, Berlin, Germany; 7.Max Delbruck Ctr Mol Med, Transgen Core Facil, Robert Rossle Str 10, Berlin, Germany; 8.Berlin Inst Hlth, Kapelle Ufer 2, Berlin, Germany |
推荐引用方式 GB/T 7714 | Piwecka, Monika,Glazar, Petar,Hernandez-Miranda, Luis R.,et al. Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function[J]. SCIENCE,2017,357(6357). |
APA | Piwecka, Monika.,Glazar, Petar.,Hernandez-Miranda, Luis R..,Memczak, Sebastian.,Wolf, Susanne A..,...&Rajewsky, Nikolaus.(2017).Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.SCIENCE,357(6357). |
MLA | Piwecka, Monika,et al."Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function".SCIENCE 357.6357(2017). |
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