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DOI | 10.1175/JCLI-D-16-0033.1 |
Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis | |
Herault, Aurelie1; Binnewies, Mikhail1; Leong, Stephanie1; Calero-Nieto, Fernando2; Zhang, Si Yi1; Kang, Yoon-A1; Wang, Xiaonan2; Pietras, Eric M.1; Chu, S. Haihua3,4; Barry-Holson, Keegan1; Armstrong, Scott3,4; Gottgens, Berthold2; Passegue, Emmanuelle1,5 | |
2017-04-06 | |
发表期刊 | NATURE |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 544期号:7648页码:53-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; England |
英文摘要 | Although many aspects of blood production are well understood, the spatial organization of myeloid differentiation in the bone marrow remains unknown. Here we use imaging to track granulocyte/macrophage progenitor (GMP) behaviour in mice during emergency and leukaemic myelopoiesis. In the steady state, we find individual GMPs scattered throughout the bone marrow. During regeneration, we observe expanding GMP patches forming defined GMP clusters, which, in turn, locally differentiate into granulocytes. The timed release of important bone marrow niche signals (SCF, IL-1 beta, G-CSF, TGF beta and CXCL4) and activation of an inducible Irf8 and beta-catenin progenitor self-renewal network control the transient formation of regenerating GMP clusters. In leukaemia, we show that GMP clusters are constantly produced owing to persistent activation of the self-renewal network and a lack of termination cytokines that normally restore haematopoietic stem-cell quiescence. Our results uncover a previously unrecognized dynamic behaviour of GMPs in situ, which tunes emergency myelopoiesis and is hijacked in leukaemia. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000398323300031 |
WOS关键词 | HEMATOPOIETIC STEM-CELLS ; TRANSCRIPTION FACTOR ; WNT/BETA-CATENIN ; RNA-SEQ ; MICE ; GENE ; MEGAKARYOCYTES ; RECEPTOR ; HETEROGENEITY ; QUIESCENCE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/19691 |
专题 | 气候变化 |
作者单位 | 1.Univ Calif San Francisco, Div Hematol Oncol, Dept Med, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA; 2.Univ Cambridge, Dept Haematol, Cambridge Inst Med Res, Wellcome Trust & MRC Cambridge Stem Cell Inst, Hills Rd, Cambridge CB2 0XY, England; 3.Harvard Med Sch, Dept Pediat Oncol, Dana Farber Canc Inst, Boston, MA 02215 USA; 4.Harvard Med Sch, Boston Childrens Hosp, Div Hematol Oncol, Boston, MA 02215 USA; 5.Columbia Univ, Med Ctr, Dept Genet & Dev, Columbia Stem Cell Initiat, New York, NY 10032 USA |
推荐引用方式 GB/T 7714 | Herault, Aurelie,Binnewies, Mikhail,Leong, Stephanie,et al. Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis[J]. NATURE,2017,544(7648):53-+. |
APA | Herault, Aurelie.,Binnewies, Mikhail.,Leong, Stephanie.,Calero-Nieto, Fernando.,Zhang, Si Yi.,...&Passegue, Emmanuelle.(2017).Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.NATURE,544(7648),53-+. |
MLA | Herault, Aurelie,et al."Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis".NATURE 544.7648(2017):53-+. |
条目包含的文件 | 条目无相关文件。 |
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