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DOI | 10.1126/science.aam9046 |
Fertile offspring from sterile sex chromosome trisomic mice | |
Hirota, Takayuki1; Ohta, Hiroshi2,3; Powell, Benjamin E.1; Mahadevaiah, Shantha K.1; Ojarikre, Obah A.1; Saitou, Mitinori2,3,4,5; Turner, James M. A.1 | |
2017-09-01 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6354页码:932-934 |
文章类型 | Article |
语种 | 英语 |
国家 | England; Japan |
英文摘要 | Having the correct number of chromosomes is vital for normal development and health. Sex chromosome trisomy affects 0.1% of the human population and is associated with infertility. We show that during reprogramming to induced pluripotent stem cells (iPSCs), fibroblasts from sterile trisomic XXYand XYYmice lose the extra sex chromosome through a phenomenon we term trisomy-biased chromosome loss (TCL). Resulting euploid XY iPSCs can be differentiated into the male germ cell lineage and functional sperm that can be used in intracytoplasmic sperm injection to produce chromosomally normal, fertile offspring. Sex chromosome loss is comparatively infrequent during mouse XX and XY iPSC generation. TCL also applies to other chromosomes, generating euploid iPSCs from cells of a Down syndrome mouse model. It can also create euploid iPSCs from human trisomic patient fibroblasts. The findings have relevance to overcoming infertility and other trisomic phenotypes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000408734900046 |
WOS关键词 | PLURIPOTENT STEM-CELLS ; DOWN-SYNDROME ; GERM-CELLS ; MOUSE ; FATE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196772 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Francis Crick Inst, Sex Chromosome Biol Lab, London NW1 1AT, England; 2.Kyoto Univ, Grad Sch Med, Dept Anat & Cell Biol, Kyoto 6068501, Japan; 3.Japan Sci & Technol Agcy JST, Exploratory Res Adv Technol ERATO, Kyoto, Japan; 4.Kyoto Univ, Ctr iPS Cell Res & Applicat CiRA, Kyoto 6068507, Japan; 5.Kyoto Univ, Inst Integrated Cell Mat Sci iCeMS, Kyoto 6068501, Japan |
推荐引用方式 GB/T 7714 | Hirota, Takayuki,Ohta, Hiroshi,Powell, Benjamin E.,et al. Fertile offspring from sterile sex chromosome trisomic mice[J]. SCIENCE,2017,357(6354):932-934. |
APA | Hirota, Takayuki.,Ohta, Hiroshi.,Powell, Benjamin E..,Mahadevaiah, Shantha K..,Ojarikre, Obah A..,...&Turner, James M. A..(2017).Fertile offspring from sterile sex chromosome trisomic mice.SCIENCE,357(6354),932-934. |
MLA | Hirota, Takayuki,et al."Fertile offspring from sterile sex chromosome trisomic mice".SCIENCE 357.6354(2017):932-934. |
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