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DOI | 10.1126/science.aan0677 |
The intestinal microbiota regulates body composition through NFIL3 and the circadian clock | |
Wang, Yuhao1; Kuang, Zheng1; Yu, Xiaofei1,5; Ruhn, Kelly A.1; Kubo, Masato2,3; Hooper, Lora V.1,4 | |
2017-09-01 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6354页码:913-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Japan |
英文摘要 | The intestinal microbiota has been identified as an environmental factor that markedly affects energy storage and body-fat accumulation in mammals, yet the underlying mechanisms remain unclear. Here we show that the microbiota regulates body composition through the circadian transcription factor NFIL3. Nfil3 transcription oscillates diurnally in intestinal epithelial cells, and the amplitude of the circadian oscillation is controlled by the microbiota through group 3 innate lymphoid cells, STAT3 (signal transducer and activator of transcription 3), and the epithelial cell circadian clock. NFIL3 controls expression of a circadian lipid metabolic program and regulates lipid absorption and export in intestinal epithelial cells. These findings provide mechanistic insight into how the intestinal microbiota regulates body composition and establish NFIL3 as an essential molecular link among the microbiota, the circadian clock, and host metabolism. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000408734900041 |
WOS关键词 | ROR-GAMMA-T ; INSULIN-RESISTANCE ; DENDRITIC CELLS ; KNOCKOUT MICE ; HOMEOSTASIS ; PROMOTES ; OBESITY ; HOST ; DIFFERENTIATION ; EPITHELIUM |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196770 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Texas Southwestern Med Ctr Dallas, Dept Immunol, Dallas, TX 75390 USA; 2.RIKEN, Yokohama Inst, Ctr Integrat Med Sci, Lab Cytokine Regulat, Suehiro Cho 1-7-22, Yokohama, Kanagawa 2300045, Japan; 3.Tokyo Sci Univ, Res Inst Biomed Sci, Div Mol Pathol, 2669 Yamazaki, Chiba 2780022, Japan; 4.Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA; 5.Rockefeller Univ, Lab Mol Genet, New York, NY 10065 USA |
推荐引用方式 GB/T 7714 | Wang, Yuhao,Kuang, Zheng,Yu, Xiaofei,et al. The intestinal microbiota regulates body composition through NFIL3 and the circadian clock[J]. SCIENCE,2017,357(6354):913-+. |
APA | Wang, Yuhao,Kuang, Zheng,Yu, Xiaofei,Ruhn, Kelly A.,Kubo, Masato,&Hooper, Lora V..(2017).The intestinal microbiota regulates body composition through NFIL3 and the circadian clock.SCIENCE,357(6354),913-+. |
MLA | Wang, Yuhao,et al."The intestinal microbiota regulates body composition through NFIL3 and the circadian clock".SCIENCE 357.6354(2017):913-+. |
条目包含的文件 | 条目无相关文件。 |
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