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DOI | 10.1126/science.aan3174 |
Glia relay differentiation cues to coordinate neuronal development in Drosophila | |
Fernandes, Vilaiwan M.1; Chen, Zhenqing1,2; Rossi, Anthony M.1; Zipfel, Jaqueline1,3; Desplan, Claude1 | |
2017-09-01 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6354页码:886-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Germany |
英文摘要 | Neuronal birth and specification must be coordinated across the developing brain to generate the neurons that constitute neural circuits. We used the Drosophila visual system to investigate how development is coordinated to establish retinotopy, a feature of all visual systems. Photoreceptors achieve retinotopy by inducing their target field in the optic lobe, the lamina neurons, with a secreted differentiation cue, epidermal growth factor (EGF). We find that communication between photoreceptors and lamina cells requires a signaling relay through glia. In response to photoreceptor-EGF, glia produce insulin-like peptides, which induce lamina neuronal differentiation. Our study identifies a role for glia in coordinating neuronal development across distinct brain regions, thus reconciling the timing of column assembly with that of delayed differentiation, as well as the spatiotemporal pattern of lamina neuron differentiation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000408734900036 |
WOS关键词 | INSULIN-LIKE PEPTIDES ; VISUAL-SYSTEM ; RETINAL AXONS ; GROWTH-CONTROL ; STEM-CELLS ; EYE ; RECEPTOR ; TARGET ; NEUROGENESIS ; CARTRIDGE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196769 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.NYU, Dept Biol, 100 Washington Sq East, New York, NY 10003 USA; 2.Univ Illinois, Carl R Woese Inst Genom Biol, Dept Cell & Dev Biol, Urbana, IL 61801 USA; 3.Inst Neuro & Verhaltensbiol, Badestr 9, D-48149 Munster, Germany |
推荐引用方式 GB/T 7714 | Fernandes, Vilaiwan M.,Chen, Zhenqing,Rossi, Anthony M.,et al. Glia relay differentiation cues to coordinate neuronal development in Drosophila[J]. SCIENCE,2017,357(6354):886-+. |
APA | Fernandes, Vilaiwan M.,Chen, Zhenqing,Rossi, Anthony M.,Zipfel, Jaqueline,&Desplan, Claude.(2017).Glia relay differentiation cues to coordinate neuronal development in Drosophila.SCIENCE,357(6354),886-+. |
MLA | Fernandes, Vilaiwan M.,et al."Glia relay differentiation cues to coordinate neuronal development in Drosophila".SCIENCE 357.6354(2017):886-+. |
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