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DOI | 10.1126/science.aaf4918 |
A central neural circuit for itch sensation | |
Mu, Di1,2; Deng, Juan1,2; Liu, Ke-Fei1,4; Wu, Zhen-Yu3; Shi, Yu-Feng1; Guo, Wei-Min1; Mao, Qun-Quan1; Liu, Xing-Jun1,5; Li, Hui3; Sun, Yan-Gang1 | |
2017-08-18 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6352页码:695-698 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | Although itch sensation is an important protective mechanism for animals, chronic itch remains a challenging clinical problem. Itch processing has been studied extensively at the spinal level. However, how itch information is transmitted to the brain and what central circuits underlie the itch-induced scratching behavior remain largely unknown. We found that the spinoparabrachial pathway was activated during itch processing and that optogenetic suppression of this pathway impaired itch-induced scratching behaviors. Itch-mediating spinal neurons, which express the gastrin-releasing peptide receptor, are disynaptically connected to the parabrachial nucleus via glutamatergic spinal projection neurons. Blockade of synaptic output of glutamatergic neurons in the parabrachial nucleus suppressed pruritogen-induced scratching behavior. Thus, our studies reveal a central neural circuit that is critical for itch signal processing. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000407793600037 |
WOS关键词 | LAMINA-I NEURONS ; SPINAL-CORD ; TRACT NEURONS ; INTERNEURONS ; PAIN ; PROJECTION ; RECEPTORS ; HISTAMINE ; MONKEY ; CELLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196699 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, State Key Lab Neurosci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China; 2.Univ Chinese Acad Sci, 19A Yu Quan Rd, Beijing 100049, Peoples R China; 3.Fourth Mil Med Univ, Dept Anat Histol & Embryol, KK Leung Brain Res Ctr, Xian 710032, Shaanxi, Peoples R China; 4.Yale Univ, Sch Med, Dept Psychiat, 333 Cedar St, New Haven, CT 06511 USA; 5.Xuzhou Med Univ, Sch Anesthesiol, Jiangsu Prov Key Lab Anesthesiol, Xuzhou 221004, Jiangsu, Peoples R China |
推荐引用方式 GB/T 7714 | Mu, Di,Deng, Juan,Liu, Ke-Fei,et al. A central neural circuit for itch sensation[J]. SCIENCE,2017,357(6352):695-698. |
APA | Mu, Di.,Deng, Juan.,Liu, Ke-Fei.,Wu, Zhen-Yu.,Shi, Yu-Feng.,...&Sun, Yan-Gang.(2017).A central neural circuit for itch sensation.SCIENCE,357(6352),695-698. |
MLA | Mu, Di,et al."A central neural circuit for itch sensation".SCIENCE 357.6352(2017):695-698. |
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