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DOI | 10.1126/science.aam5336 |
The microbial metabolite desaminotyrosine protects from influenza through type I interferon | |
Steed, Ashley L.1,3; Christophi, George P.2,3; Kaiko, Gerard E.3; Sun, Lulu3; Goodwin, Victoria M.1,3; Jain, Umang3; Esaulova, Ekaterina3,4; Artyomov, Maxim N.3; Morales, David J.2,3; Holtzman, Michael J.2; Boon, Adrianus C. M.2,3,5; Lenschow, Deborah J.2,3; Stappenbeck, Thaddeus S.3 | |
2017-08-04 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6350页码:498-502 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Russia |
英文摘要 | The microbiota is known to modulate the host response to influenza infection through as-yet-unclear mechanisms. We hypothesized that components of the microbiota exert effects through type I interferon (IFN), a hypothesis supported by analysis of influenza in a gain-of-function genetic mouse model. Here we show that a microbially associated metabolite, desaminotyrosine (DAT), protects from influenza through augmentation of type I IFN signaling and diminution of lung immunopathology. A specific human-associated gut microbe, Clostridium orbiscindens, produced DAT and rescued antibiotic-treated influenza-infected mice. DAT protected the host by priming the amplification loop of type I IFN signaling. These findings show that specific components of the enteric microbiota have distal effects on responses to lethal infections through modulation of type I IFN. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000406840100037 |
WOS关键词 | ACUTE LUNG INJURY ; A VIRUS ; COMMENSAL BACTERIA ; ANTIVIRAL IMMUNITY ; DIETARY FIBER ; H5N1 VIRUSES ; INFECTION ; CELLS ; INDUCTION ; DISEASE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196607 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA; 2.Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA; 3.Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA; 4.St Petersburg Natl Res Univ Informat Technol Mech, Comp Technol Dept, St Petersburg 197101, Russia; 5.Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA |
推荐引用方式 GB/T 7714 | Steed, Ashley L.,Christophi, George P.,Kaiko, Gerard E.,et al. The microbial metabolite desaminotyrosine protects from influenza through type I interferon[J]. SCIENCE,2017,357(6350):498-502. |
APA | Steed, Ashley L..,Christophi, George P..,Kaiko, Gerard E..,Sun, Lulu.,Goodwin, Victoria M..,...&Stappenbeck, Thaddeus S..(2017).The microbial metabolite desaminotyrosine protects from influenza through type I interferon.SCIENCE,357(6350),498-502. |
MLA | Steed, Ashley L.,et al."The microbial metabolite desaminotyrosine protects from influenza through type I interferon".SCIENCE 357.6350(2017):498-502. |
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