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DOI | 10.1126/science.aan0218 |
UBE2O remodels the proteome during terminal erythroid differentiation | |
Nguyen, Anthony T.1; Prado, Miguel A.1; Schmidt, Paul J.2,3; Sendamarai, Anoop K.2,3; Wilson-Grady, Joshua T.1; Min, Mingwei1,6; Campagna, Dean R.2,3; Tian, Geng1; Shi, Yuan1,7; Dederer, Verena1,8; Kawan, Mona1,8; Kuehnle, Nathalie1,8; Paulo, Joao A.1; Yao, Yu4; Weiss, Mitchell J.4; Justice, Monica J.5; Gygi, Steven P.1; Fleming, Mark D.2,3; Finley, Daniel1 | |
2017-08-04 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6350 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Canada; Germany |
英文摘要 | During terminal differentiation, the global protein complement is remodeled, as epitomized by erythrocytes, whose cytosol is similar to 98% globin. The erythroid proteome undergoes a rapid transition at the reticulocyte stage; however, the mechanisms driving programmed elimination of preexisting cytosolic proteins are unclear. We found that a mutation in the murine Ube2o gene, which encodes a ubiquitin-conjugating enzyme induced during erythropoiesis, results in anemia. Proteomic analysis suggested that UBE2O is a broad-spectrum ubiquitinating enzyme that remodels the erythroid proteome. In particular, ribosome elimination, a hallmark of reticulocyte differentiation, was defective in Ube2o(-/-) mutants. UBE2O recognized ribosomal proteins and other substrates directly, targeting them to proteasomes for degradation. Thus, in reticulocytes, the induction of ubiquitinating factors may drive the transition from a complex to a simple proteome. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000406840100029 |
WOS关键词 | RETICULOCYTE MATURATION ; UBIQUITIN PROTEASE ; RIBOSOMES ; AUTOPHAGY ; MONOUBIQUITINATION ; ERYTHROPOIESIS ; UBIQUITYLATION ; ACTIVATION ; INHIBITION ; STARVATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196600 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA; 2.Boston Childrens Hosp, Dept Pathol, Boston, MA 02115 USA; 3.Harvard Med Sch, Boston, MA 02115 USA; 4.St Jude Childrens Res Hosp, Dept Hematol, Memphis, TN 38105 USA; 5.Hosp Sick Children, Peter Gilgan Ctr Res & Learning, Genet & Genome Biol Program, Toronto, ON M5G 0A4, Canada; 6.Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA; 7.Univ Calif Los Angeles, Dept Mol & Clin Pharmacol, Los Angeles, CA 90095 USA; 8.Heidelberg Univ, Zentrum Mol Biol, D-69120 Heidelberg, Germany |
推荐引用方式 GB/T 7714 | Nguyen, Anthony T.,Prado, Miguel A.,Schmidt, Paul J.,et al. UBE2O remodels the proteome during terminal erythroid differentiation[J]. SCIENCE,2017,357(6350). |
APA | Nguyen, Anthony T..,Prado, Miguel A..,Schmidt, Paul J..,Sendamarai, Anoop K..,Wilson-Grady, Joshua T..,...&Finley, Daniel.(2017).UBE2O remodels the proteome during terminal erythroid differentiation.SCIENCE,357(6350). |
MLA | Nguyen, Anthony T.,et al."UBE2O remodels the proteome during terminal erythroid differentiation".SCIENCE 357.6350(2017). |
条目包含的文件 | 条目无相关文件。 |
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