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DOI | 10.1126/science.aan3721 |
Control of species-dependent cortico-motoneuronal connections underlying manual dexterity | |
Gu, Zirong1; Kalamboglas, John2,3; Yoshioka, Shin1; Han, Wenqi4; Li, Zhuo4,5; Kawasawa, Yuka Imamura4,6,7; Pochareddy, Sirisha4; Li, Zhen4; Liu, Fuchen4; Xu, Xuming4; Wijeratne, Sagara8; Ueno, Masaki1,9; Blatz, Emily1; Salomone, Joseph1; Kumanogoh, Atsushi10; Rasin, Mladen-Roko8; Gebelein, Brian1; Weirauch, Matthew T.11,12; Sestan, Nenad4; Martin, John H.2,3,9; Yoshida, Yutaka1 | |
2017-07-28 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6349页码:400-404 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Peoples R China; Japan |
英文摘要 | Superior manual dexterity in higher primates emerged together with the appearance of cortico-motoneuronal (CM) connections during the evolution of the mammalian corticospinal (CS) system. Previously thought to be specific to higher primates, we identified transient CM connections in early postnatal mice, which are eventually eliminated by Sema6D-PlexA1 signaling. PlexA1 mutant mice maintain CM connections into adulthood and exhibit superior manual dexterity as compared with that of controls. Last, differing PlexA1 expression in layer 5 of the motor cortex, which is strong in wild-type mice but weak in humans, may be explained by FEZF2-mediated cis-regulatory elements that are found only in higher primates. Thus, species-dependent regulation of PlexA1 expression may have been crucial in the evolution of mammalian CS systems that improved fine motor control in higher primates. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000406362300045 |
WOS关键词 | CORTICOMOTONEURONAL CONNECTIONS ; MOTOR CONTROL ; SPINAL-CORD ; NEURONS ; GENES ; CELLS ; RATS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196547 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.CCHMC, Div Dev Biol, Cincinnati, OH 45229 USA; 2.CUNY, Sch Med, Dept Cellular Mol & Biomed Sci, New York, NY 10031 USA; 3.CUNY, Grad Ctr, New York, NY 10017 USA; 4.Yale Sch Med, Kavli Inst Neurosci, Dept Neurosci, New Haven, CT 06510 USA; 5.Zhengzhou Univ, Basic Med Sch, Zhengzhou, Henan, Peoples R China; 6.Penn State Coll Med, Dept Biochem, Inst Personalized Med, Hershey, PA 17033 USA; 7.Penn State Coll Med, Dept Mol Biol & Pharmacol, Inst Personalized Med, Hershey, PA 17033 USA; 8.Rutgers State Univ, Robert Wood Johnson Med Sch, Dept Neurosci & Cell Biol, Piscataway, NJ 08854 USA; 9.Japan Sci & Technol Agcy JST, Precursory Res Embryon Sci & Technol PRESTO, Kawaguchi, Saitama 3320012, Japan; 10.Osaka Univ, Grad Sch Med, Dept Resp Med & Clin Immunol, Suita, Osaka 5650871, Japan; 11.Cincinnati Childrens Hosp Med Ctr, Div Biomed Informat, Ctr Autoimmune Genom & Etiol, Cincinnati, OH 45229 USA; 12.Cincinnati Childrens Hosp Med Ctr, Div Dev Biol, Cincinnati, OH 45229 USA |
推荐引用方式 GB/T 7714 | Gu, Zirong,Kalamboglas, John,Yoshioka, Shin,et al. Control of species-dependent cortico-motoneuronal connections underlying manual dexterity[J]. SCIENCE,2017,357(6349):400-404. |
APA | Gu, Zirong.,Kalamboglas, John.,Yoshioka, Shin.,Han, Wenqi.,Li, Zhuo.,...&Yoshida, Yutaka.(2017).Control of species-dependent cortico-motoneuronal connections underlying manual dexterity.SCIENCE,357(6349),400-404. |
MLA | Gu, Zirong,et al."Control of species-dependent cortico-motoneuronal connections underlying manual dexterity".SCIENCE 357.6349(2017):400-404. |
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