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DOI | 10.1126/science.aan2762 |
Response to Comments on "The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport" | |
O&1; 39;Brien, Elizabeth2 | |
2017-07-21 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6348 |
文章类型 | Editorial Material |
语种 | 英语 |
国家 | USA |
英文摘要 | Baranovskiy et al. and Pellegrini argue that, based on structural data, the path for charge transfer through the [4Fe4S] domain of primase is not feasible. Our manuscript presents electrochemical data directly showing charge transport through DNA to the [4Fe4S] cluster of a primase p58C construct and a reversible switch in the DNA-bound signal with oxidation/reduction, which is inhibited by mutation of three tyrosine residues. Although the dispositions of tyrosines differ in different constructs, all are within range for microsecond electron transfer. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000405901600002 |
WOS关键词 | C-TERMINAL DOMAIN ; SUBUNIT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196503 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA; 2.Vanderbilt Univ, Struct Biol Ctr, Dept Biochem, 221 Kirkland Hall, Nashville, TN 37235 USA; 3.Vanderbilt Univ, Dept Chem, Struct Biol Ctr, Box 1583, Nashville, TN 37235 USA |
推荐引用方式 GB/T 7714 | O&,39;Brien, Elizabeth. Response to Comments on "The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport"[J]. SCIENCE,2017,357(6348). |
APA | O&,&39;Brien, Elizabeth.(2017).Response to Comments on "The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport".SCIENCE,357(6348). |
MLA | O&,et al."Response to Comments on "The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport"".SCIENCE 357.6348(2017). |
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