Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aag1095 |
Guanine glycation repair by DJ-1/Park7 and its bacterial homologs | |
Richarme, Gilbert1,2; Liu, Cailing3; Mihoub, Mouadh1; Abdallah, Jad1,4; Leger, Thibaut5; Joly, Nicolas6; Liebart, Jean-Claude1; Jurkunas, Ula V.3; Nadal, Marc7; Bouloc, Philippe8; Dairou, Julien2; Lamouri, Aazdine9 | |
2017-07-14 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6347页码:208-211 |
文章类型 | Article |
语种 | 英语 |
国家 | France; USA; Lebanon |
英文摘要 | DNA damage induced by reactive carbonyls (mainly methylglyoxal and glyoxal), called DNA glycation, is quantitatively as important as oxidative damage. DNA glycation is associated with increased mutation frequency, DNA strand breaks, and cytotoxicity. However, in contrast to guanine oxidation repair, how glycated DNA is repaired remains undetermined. Here, we found that the parkinsonism-associated protein DJ-1 and its bacterial homologs Hsp31, YhbO, and YajL could repair methylglyoxal-and glyoxal-glycated nucleotides and nucleic acids. DJ-1-depleted cells displayed increased levels of glycated DNA, DNA strand breaks, and phosphorylated p53. Deglycase-deficient bacterial mutants displayed increased levels of glycated DNA and RNA and exhibited strong mutator phenotypes. Thus, DJ-1 and its prokaryotic homologs constitute a major nucleotide repair system that we name guanine glycation repair. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000405391700048 |
WOS关键词 | PROTEIN DJ-1/PARK7 ; MUTANT DEFICIENT ; DNA ; METHYLGLYOXAL ; NUCLEOTIDE ; STRESS ; DAMAGE ; DJ-1 ; YAJL ; GLYOXAL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196470 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Paris Diderot, UMR7592, Inst Jacques Monod, Stress Mol, 15 Rue Helene Brion, F-75013 Paris, France; 2.Univ Paris 05, Sorbonne Paris Cite, UMR 8601, Chim & Biochim Pharmacol & Toxicol, F-75270 Paris, France; 3.Harvard Med Sch, Massachusetts Eye & Ear Infirm, Schepens Eye Res Inst, Dept Ophthalmol, Boston, MA 02114 USA; 4.Lebanese Amer Univ, Sch Pharm, Byblos 20381401, Lebanon; 5.Univ Paris Diderot, UMR7592, Inst Jacques Monod, Prote Facil, F-75013 Paris, France; 6.Univ Paris Diderot, UMR7592, Inst Jacques Monod, Cellular Cycle & Dev, F-75013 Paris, France; 7.Univ Paris Diderot, CNRS, UMR7592, Inst Jacques Monod, F-75013 Paris, France; 8.Univ Paris Saclay, Univ Paris Sud, CNRS, I2BC,Commissariat Energie Atom & Energies Alterna, F-91198 Gif Sur Yvette, France; 9.Univ Paris Diderot, UMR 7086, Interfaces Traitements Org & Dynam Syst ITODYS, 15 Rue J-A de Baif, F-75013 Paris, France |
推荐引用方式 GB/T 7714 | Richarme, Gilbert,Liu, Cailing,Mihoub, Mouadh,et al. Guanine glycation repair by DJ-1/Park7 and its bacterial homologs[J]. SCIENCE,2017,357(6347):208-211. |
APA | Richarme, Gilbert.,Liu, Cailing.,Mihoub, Mouadh.,Abdallah, Jad.,Leger, Thibaut.,...&Lamouri, Aazdine.(2017).Guanine glycation repair by DJ-1/Park7 and its bacterial homologs.SCIENCE,357(6347),208-211. |
MLA | Richarme, Gilbert,et al."Guanine glycation repair by DJ-1/Park7 and its bacterial homologs".SCIENCE 357.6347(2017):208-211. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论