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DOI | 10.1126/science.aak9726 |
History of winning remodels thalamo-PFC circuit to reinforce social dominance | |
Zhou, Tingting1,2,3,4,5; Zhu, Hong1,2,3,4,5; Fan, Zhengxiao4,5; Wang, Fei1,2,3; Chen, Yang1,2; Liang, Hexing4,5; Yang, Zhongfei1,2; Zhang, Lu6; Lin, Longnian7; Zhan, Yang8; Wang, Zheng1,2; Hu, Hailan4,5,9 | |
2017-07-14 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6347页码:162-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | Mental strength and history of winning play an important role in the determination of social dominance. However, the neural circuits mediating these intrinsic and extrinsic factors have remained unclear. Working in mice, we identified a dorsomedial prefrontal cortex (dmPFC) neural population showing "effort"-related firing during moment-to-moment competition in the dominance tube test. Activation or inhibition of the dmPFC induces instant winning or losing, respectively. In vivo optogenetic-based long-term potentiation and depression experiments establish that the mediodorsal thalamic input to the dmPFC mediates long-lasting changes in the social dominance status that are affected by history of winning. The same neural circuit also underlies transfer of dominance between different social contests. These results provide a framework for understanding the circuit basis of adaptive and pathological social behaviors. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000405391700037 |
WOS关键词 | MEDIAL PREFRONTAL CORTEX ; DECISION-MAKING ; FRONTAL-CORTEX ; BEHAVIOR ; HIERARCHY ; RAT ; MECHANISMS ; MODULATION ; CONFLICT ; WINNER |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196467 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Shanghai 200031, Peoples R China; 3.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China; 4.Zhejiang Univ, Qiushi Acad Adv Studies, Interdisciplinary Inst Neurosci & Technol, Hangzhou 310012, Zhejiang, Peoples R China; 5.Zhejiang Univ, Sch Med, Minist Hlth China, Key Lab Med Neurobiol,Ctr Neurosci, Hangzhou 310058, Zhejiang, Peoples R China; 6.Fudan Univ, Shanghai Ctr Math Sci, Shanghai 200433, Peoples R China; 7.East China Normal Univ, Key Lab Brain Funct Gen, Shanghai 200062, Peoples R China; 8.Chinese Acad Sci, Shenzhen Inst Adv Technol, Brain Cognit & Brain Dis Inst, Shenzhen 518055, Peoples R China; 9.Zhejiang Univ, Sch Med, Mental Hlth Ctr, Hangzhou 310013, Zhejiang, Peoples R China |
推荐引用方式 GB/T 7714 | Zhou, Tingting,Zhu, Hong,Fan, Zhengxiao,et al. History of winning remodels thalamo-PFC circuit to reinforce social dominance[J]. SCIENCE,2017,357(6347):162-+. |
APA | Zhou, Tingting.,Zhu, Hong.,Fan, Zhengxiao.,Wang, Fei.,Chen, Yang.,...&Hu, Hailan.(2017).History of winning remodels thalamo-PFC circuit to reinforce social dominance.SCIENCE,357(6347),162-+. |
MLA | Zhou, Tingting,et al."History of winning remodels thalamo-PFC circuit to reinforce social dominance".SCIENCE 357.6347(2017):162-+. |
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