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DOI | 10.1126/science.aaf4612 |
Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling | |
Blundon, Jay A.1; Roy, Noah C.1; Teubner, Brett J. W.1; Yu, Jing1; Eom, Tae-Yeon1; Sample, K. Jake1; Pani, Amar1,5; Smeyne, Richard J.1,6; Han, Seung Baek1; Kerekes, Ryan A.2; Rose, Derek C.2; Hackett, Troy A.3; Vuppala, Pradeep K.4,7; Freeman, Burgess B., III4; Zakharenko, Stanislav S.1 | |
2017-06-30 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6345页码:1352-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Circuits in the auditory cortex are highly susceptible to acoustic influences during an early postnatal critical period. The auditory cortex selectively expands neural representations of enriched acoustic stimuli, a process important for human language acquisition. Adults lack this plasticity. Here we show in the murine auditory cortex that juvenile plasticity can be reestablished in adulthood if acoustic stimuli are pairedwith disruption of ecto-5'-nucleotidase-dependent adenosine production or A(1)-adenosine receptor signaling in the auditory thalamus. This plasticity occurs at the level of cortical maps and individual neurons in the auditory cortex of awake adult mice and is associated with long-term improvement of tone-discrimination abilities. We conclude that, in adult mice, disrupting adenosine signaling in the thalamus rejuvenates plasticity in the auditory cortex and improves auditory perception. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000404351500030 |
WOS关键词 | VAGUS NERVE-STIMULATION ; LONG-TERM POTENTIATION ; CRITICAL PERIOD ; SYNAPTIC PLASTICITY ; REPRESENTATION ; MEMORY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196370 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.St Jude Childrens Res Hosp, Dept Dev Neurobiol, 332 N Lauderdale St, Memphis, TN 38105 USA; 2.Oak Ridge Natl Lab, Elect & Elect Syst Res Div, Oak Ridge, TN 37831 USA; 3.Vanderbilt Univ, Sch Med, Dept Hearing & Speech Sci, Nashville, TN 37232 USA; 4.St Jude Childrens Res Hosp, Preclin Pharmacokinet Shared Resource, 332 N Lauderdale St, Memphis, TN 38105 USA; 5.Univ Tennessee, Ctr Hlth Sci, 855 Monroe Ave, Memphis, TN 38163 USA; 6.Thomas Jefferson Univ, 233 South 10th St,Bluemle Hall,Room 208, Philadelphia, PA 19107 USA; 7.KinderPharm, 100 Arrandale Blvd,Suite 101, Exton, PA 19341 USA |
推荐引用方式 GB/T 7714 | Blundon, Jay A.,Roy, Noah C.,Teubner, Brett J. W.,et al. Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling[J]. SCIENCE,2017,356(6345):1352-+. |
APA | Blundon, Jay A..,Roy, Noah C..,Teubner, Brett J. W..,Yu, Jing.,Eom, Tae-Yeon.,...&Zakharenko, Stanislav S..(2017).Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling.SCIENCE,356(6345),1352-+. |
MLA | Blundon, Jay A.,et al."Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling".SCIENCE 356.6345(2017):1352-+. |
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