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DOI | 10.1126/science.aam6892 |
Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150 | |
Yu, Xuekui1,2; Jih, Jonathan1,2; Jiang, Jiansen2; Zhou, Z. Hong1,2 | |
2017-06-30 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6345 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Herpesviruses possess a genome-pressurized capsid. The 235-kilobase genome of human cytomegalovirus (HCMV) is by far the largest of any herpesvirus, yet it has been unclear how its capsid, which is similar in size to those of other herpesviruses, is stabilized. Here we report a HCMV atomic structure consisting of the herpesvirus-conserved capsid proteins MCP, Tri1, Tri2, and SCP and the HCMV-specific tegument protein pp150-totaling similar to 4000 molecules and 62 different conformers. MCPs manifest as a complex of insertions around a bacteriophage HK97 gp5-like domain, which gives rise to three classes of capsid floor-defining interactions; triplexes, composed of two "embracing" Tri2 conformers and a "third-wheeling" Tri1, fasten the capsid floor. HCMV-specific strategies include using hexon channels to accommodate the genome and pp150 helix bundles to secure the capsid via cysteine tetrad-to-SCP interactions. Our structure should inform rational design of countermeasures against HCMV, other herpesviruses, and even HIV/AIDS. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000404351500028 |
WOS关键词 | CRYO ELECTRON-MICROSCOPY ; HIGHLY PATHOGENIC SIV ; PROTEIN ; VIRUS ; DNA ; SYSTEM ; HERPESVIRUSES ; VISUALIZATION ; PREDICTION ; INFECTION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196361 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA; 2.Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA |
推荐引用方式 GB/T 7714 | Yu, Xuekui,Jih, Jonathan,Jiang, Jiansen,et al. Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150[J]. SCIENCE,2017,356(6345). |
APA | Yu, Xuekui,Jih, Jonathan,Jiang, Jiansen,&Zhou, Z. Hong.(2017).Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150.SCIENCE,356(6345). |
MLA | Yu, Xuekui,et al."Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150".SCIENCE 356.6345(2017). |
条目包含的文件 | 条目无相关文件。 |
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