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DOI | 10.1126/science.aag2770 |
Chemical transformation of xenobiotics by the human gut microbiota | |
Koppel, Nitzan1; Rekdal, Vayu Maini1; Balskus, Emily P.1,2 | |
2017-06-23 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6344 |
文章类型 | Review |
语种 | 英语 |
国家 | USA |
英文摘要 | The human gut microbiota makes key contributions to the metabolism of ingested compounds (xenobiotics), transforming hundreds of dietary components, industrial chemicals, and pharmaceuticals into metabolites with altered activities, toxicities, and lifetimes within the body. The chemistry of gut microbial xenobiotic metabolism is often distinct from that of host enzymes. Despite their important consequences for human biology, the gut microbes, genes, and enzymes involved in xenobiotic metabolism are poorly understood. Linking these microbial transformations to enzymes and elucidating their biological effects is undoubtedly challenging. However, recent studies demonstrate that integrating traditional and emerging technologies can enable progress toward this goal. Ultimately, a molecular understanding of gut microbial xenobiotic metabolism will guide personalized medicine and nutrition, inform toxicology risk assessment, and improve drug discovery and development. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000403881700029 |
WOS关键词 | GLYCYL RADICAL ENZYME ; CHOLINE TRIMETHYLAMINE-LYASE ; HUMAN INTESTINAL MICROBIOTA ; CANCER DRUG TOXICITY ; BETA-GLUCURONIDASE ; CELIAC-DISEASE ; DIETARY FIBER ; HUMAN HEALTH ; AZO DYES ; N-OXIDE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196323 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard Univ, Dept Chem & Chem Biol, 12 Oxford St, Cambridge, MA 02138 USA; 2.Broad Inst, Cambridge, MA 02139 USA |
推荐引用方式 GB/T 7714 | Koppel, Nitzan,Rekdal, Vayu Maini,Balskus, Emily P.. Chemical transformation of xenobiotics by the human gut microbiota[J]. SCIENCE,2017,356(6344). |
APA | Koppel, Nitzan,Rekdal, Vayu Maini,&Balskus, Emily P..(2017).Chemical transformation of xenobiotics by the human gut microbiota.SCIENCE,356(6344). |
MLA | Koppel, Nitzan,et al."Chemical transformation of xenobiotics by the human gut microbiota".SCIENCE 356.6344(2017). |
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