Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aag2553 |
Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth | |
Di Malta, Chiara1; Siciliano, Diletta1; Calcagni, Alessia1; Monfregola, Jlenia1; Punzi, Simona2; Pastore, Nunzia3,4; Eastes, Andrea N.5,6; Davis, Oliver7,8; De Cegli, Rossella1; Zampelli, Angela1; Di Giovannantonio, Luca G.1; Nusco, Edoardo1; Platt, Nick9; Guida, Alessandro2; Ogmundsdottir, Margret Helga10; Lanfrancone, Luisa2; Perera, Rushika M.5,6; Zoncu, Roberto7,8; Pelicci, Pier Giuseppe2,11; Settembre, Carmine1,12,13; Ballabio, Andrea1,3,4,13 | |
2017-06-16 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6343页码:1188-1192 |
文章类型 | Article |
语种 | 英语 |
国家 | Italy; USA; England; Iceland |
英文摘要 | The mechanistic target of rapamycin complex 1 (mTORC1) is recruited to the lysosome by Rag guanosine triphosphatases (GTPases) and regulates anabolic pathways in response to nutrients. We found that MiT/TFE transcription factors-master regulators of lysosomal and melanosomal biogenesis and autophagy-control mTORC1 lysosomal recruitment and activity by directly regulating the expression of RagD. In mice, this mechanism mediated adaptation to food availability after starvation and physical exercise and played an important role in cancer growth. Up-regulation of MiT/TFE genes in cells and tissues from patients and murine models of renal cell carcinoma, pancreatic ductal adenocarcinoma, and melanoma triggered RagD-mediated mTORC1 induction, resulting in cell hyperproliferation and cancer growth. Thus, this transcriptional regulatory mechanism enables cellular adaptation to nutrient availability and supports the energy-demanding metabolism of cancer cells. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000403327400042 |
WOS关键词 | LYSOSOMAL BIOGENESIS ; AUTOPHAGY ; MUTATIONS ; CLEARANCE ; TFE3 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196288 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Telethon Inst Genet & Med TIGEM, Via Campi Flegrei 34, I-80078 Naples, Italy; 2.European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy; 3.Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA; 4.Baylor Coll Med, Neurol Res Inst, Houston, TX 77030 USA; 5.Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA; 6.Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA; 7.Univ Calif Berkeley, Dept Mol & Cellular Biol, Berkeley, CA 94720 USA; 8.Univ Calif Berkeley, Paul F Glenn Ctr Aging Res, Berkeley, CA 94720 USA; 9.Univ Oxford, Dept Pharmacol, Oxford, England; 10.Univ Iceland, Dept Biochem & Mol Biol, Vatnsmyrarvegur 16, IS-101 Reykjavik, Iceland; 11.Univ Milan, Dept Oncol, I-20139 Milan, Italy; 12.Dulbecco Telethon Inst, Via Campi Flegrei 34, I-80078 Naples, Italy; 13.Univ Naples Federico II, Dept Med & Translat Sci, Med Genet Unit, Via Pansini 5, I-80131 Naples, Italy |
推荐引用方式 GB/T 7714 | Di Malta, Chiara,Siciliano, Diletta,Calcagni, Alessia,et al. Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth[J]. SCIENCE,2017,356(6343):1188-1192. |
APA | Di Malta, Chiara.,Siciliano, Diletta.,Calcagni, Alessia.,Monfregola, Jlenia.,Punzi, Simona.,...&Ballabio, Andrea.(2017).Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.SCIENCE,356(6343),1188-1192. |
MLA | Di Malta, Chiara,et al."Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth".SCIENCE 356.6343(2017):1188-1192. |
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