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DOI | 10.1126/science.aam7671 |
miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes | |
Peng, Changgeng1; Li, Lili1; Zhang, Ming-Dong2; Gonzales, Carolina Bengtsson1; Parisien, Marc3; Belfer, Inna4; Usoskin, Dmitry1; Abdo, Hind1; Furlan, Alessandro1; Haring, Martin1; Lallemend, Francois1,2; Harkany, Tibor2,5; Diatchenko, Luda3; Hokfelt, Tomas2; Hjerling-Leffler, Jens1; Ernfors, Patrik1 | |
2017-06-16 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6343页码:1168-1171 |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden; Canada; USA; Austria |
英文摘要 | Nociception is protective and prevents tissue damage but can also facilitate chronic pain. Whether a general principle governs these two types of pain is unknown. Here, we show that both basal mechanical and neuropathic pain are controlled by the microRNA-183 (miR-183) cluster in mice. This single cluster controls more than 80% of neuropathic pain-regulated genes and scales basal mechanical sensitivity and mechanical allodynia by regulating auxiliary voltage-gated calcium channel subunits alpha 2 delta-1 and alpha 2 delta-2. Basal sensitivity is controlled in nociceptors, and allodynia involves TrkB+ light-touch mechanoreceptors. These light-touch-sensitive neurons, which normally do not elicit pain, produce pain during neuropathy that is reversed by gabapentin. Thus, a single microRNA cluster continuously scales acute noxious mechanical sensitivity in nociceptive neurons and suppresses neuropathic pain transduction in a specific, light-touch-sensitive neuronal type recruited during mechanical allodynia. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000403327400036 |
WOS关键词 | CALCIUM-CHANNELS ; EXPRESSION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196277 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, S-17177 Stockholm, Sweden; 2.Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden; 3.McGill Univ, Alan Edwards Ctr Res Pain, Montreal, PQ H3A 0G1, Canada; 4.NIH, Off Res Womens Hlth, Bldg 10, Bethesda, MD 20892 USA; 5.Med Univ Vienna, Dept Mol Neurosci, Ctr Brain Res, A-1090 Vienna, Austria |
推荐引用方式 GB/T 7714 | Peng, Changgeng,Li, Lili,Zhang, Ming-Dong,et al. miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes[J]. SCIENCE,2017,356(6343):1168-1171. |
APA | Peng, Changgeng.,Li, Lili.,Zhang, Ming-Dong.,Gonzales, Carolina Bengtsson.,Parisien, Marc.,...&Ernfors, Patrik.(2017).miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes.SCIENCE,356(6343),1168-1171. |
MLA | Peng, Changgeng,et al."miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes".SCIENCE 356.6343(2017):1168-1171. |
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