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DOI | 10.1126/science.aag3009 |
Mapping the human DC lineage through the integration of high-dimensional techniques | |
See, Peter1; Dutertre, Charles-Antoine1,2; Chen, Jinmiao1; Gunther, Patrick3; McGovern, Naomi1; Irac, Sergio Erdal2; Gunawan, Merry4; Beyer, Marc3,5,6; Handler, Kristian3; Duan, Kaibo1; Bin Sumatoh, Hermi Rizal1; Ruffin, Nicolas7; Jouve, Mabel7; Gea-Mallorqui, Ester7; Hennekam, Raoul C. M.8; Lim, Tony9; Yip, Chan Chung10; Wen, Ming2; Malleret, Benoit1,11; Low, Ivy1; Shadan, Nurhidaya Binte1; Fen, Charlene Foong Shu12; Tay, Alicia1; Lum, Josephine1; Zolezzi, Francesca1; Larbi, Anis1; Poidinger, Michael1; Chan, Jerry K. Y.1,13,14,15; Chen, Qingfeng16,17; Renia, Laurent1; Haniffa, Muzlifah4; Benaroch, Philippe7; Schlitzer, Andreas1; Schultze, Joachim L.3,5,6; Newell, Evan W.1; Ginhoux, Florent1 | |
2017-06-09 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6342 |
文章类型 | Article |
语种 | 英语 |
国家 | Singapore; Germany; England; France; Netherlands |
英文摘要 | Dendritic cells (DC) are professional antigen-presenting cells that orchestrate immune responses. The human DC population comprises two main functionally specialized lineages, whose origins and differentiation pathways remain incompletely defined. Here, we combine two high-dimensional technologies-single-cell messenger RNA sequencing (scmRNAseq) and cytometry by time-of-flight (CyTOF)-to identify human blood CD123(+)CD33(+)CD45RA(+)DC precursors (pre-DC). Pre-DC share surface markers with plasmacytoid DC (pDC) but have distinct functional properties that were previously attributed to pDC. Tracing the differentiation of DC from the bone marrow to the peripheral blood revealed that the pre-DC compartment contains distinct lineage-committed subpopulations, including one early uncommitted CD123(high) pre-DC subset and two CD45RA(+)CD123(low) lineage-committed subsets exhibiting functional differences. The discovery of multiple committed pre-DC populations opens promising new avenues for the therapeutic exploitation of DC subset-specific targeting. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000402871700045 |
WOS关键词 | PLASMACYTOID DENDRITIC CELLS ; INTERFERON-PRODUCING CELLS ; INFLUENZA-VIRUS ; T-CELLS ; RNA-SEQ ; EXPRESSION ; PROGENITOR ; SUBSETS ; TRAJECTORIES ; MACROPHAGES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196223 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 4, Singapore 138648, Singapore; 2.Duke NUS Med Sch, Program Emerging Infect Dis, 8 Coll Rd, Singapore 169857, Singapore; 3.Univ Bonn, Life & Med Sci LIMES Inst, Genom & Immunoregulat, D-32115 Bonn, Germany; 4.Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England; 5.German Ctr Neurodegenerat Dis, Platform Single Cell Genom & Epigen, D-53175 Bonn, Germany; 6.Univ Bonn, D-53175 Bonn, Germany; 7.PSL Res Univ, INSERM, U932, Inst Curie, F-75005 Paris, France; 8.Univ Amsterdam, Acad Med Ctr, Dept Pediat, Amsterdam, Netherlands; 9.Singapore Gen Hosp, Dept Anat Pathol, Singapore, Singapore; 10.Singapore Gen Hosp, Dept Hlth Promot Board HPB & Transplant Surg, Singapore, Singapore; 11.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol & Immunol, Singapore, Singapore; 12.Singapore Hlth Serv Flow Cytometry Core Platform, 20 Coll Rd,Discovery Tower Level 10, Singapore 169856, Singapore; 13.KK Womens & Childrens Hosp, Div Obstet & Gynaecol, Dept Reprod Med, Singapore, Singapore; 14.Duke NUS Grad Med Sch, Canc & Stem Cell Biol Program, Singapore, Singapore; 15.Natl Univ Singapore, Yong Loo Lin Sch Med, Expt Fetal Med Grp, Singapore, Singapore; 16.ASTAR, Humanized Mouse Unit, Inst Mol & Cell Biol, Singapore, Singapore; 17.Univ Bonn, Myeloid Cell Biol Life & Med Sci LIMES Inst, D-53115 Bonn, Germany |
推荐引用方式 GB/T 7714 | See, Peter,Dutertre, Charles-Antoine,Chen, Jinmiao,et al. Mapping the human DC lineage through the integration of high-dimensional techniques[J]. SCIENCE,2017,356(6342). |
APA | See, Peter.,Dutertre, Charles-Antoine.,Chen, Jinmiao.,Gunther, Patrick.,McGovern, Naomi.,...&Ginhoux, Florent.(2017).Mapping the human DC lineage through the integration of high-dimensional techniques.SCIENCE,356(6342). |
MLA | See, Peter,et al."Mapping the human DC lineage through the integration of high-dimensional techniques".SCIENCE 356.6342(2017). |
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