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DOI | 10.1126/science.aaj2067 |
Local amplifiers of IL-4R alpha-mediated macrophage activation promote repair in lung and liver | |
Minutti, Carlos M.1,2,3,4; Jackson-Jones, Lucy H.3,4; Garcia-Fojeda, Belen1,2; Knipper, Johanna A.3,4; Sutherland, Tara E.3,4,5; Logan, Nicola3,4; Rinqvist, Emma3,4,11; Guillamat-Prats, Raquel2,6; Ferenbach, David A.3,4; Artigas, Antonio2,6; Stamme, Cordula7,8; Chroneos, Zissis C.9; Zaiss, Dietmar M.3,4; Casals, Cristina1,2; Allen, Judith E.3,4,10 | |
2017-06-09 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6342页码:1076-1080 |
文章类型 | Article |
语种 | 英语 |
国家 | Spain; Scotland; England; Germany; USA; Sweden |
英文摘要 | The type 2 immune response controls helminth infection and maintains tissue homeostasis but can lead to allergy and fibrosis if not adequately regulated. We have discovered local tissue-specific amplifiers of type 2-mediated macrophage activation. In the lung, surfactant protein A (SP-A) enhanced interleukin-4 (IL-4)-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury after infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair after bacterial infection, but resulted in fibrosis after peritoneal dialysis. IL-4 drives production of these structurally related defense collagens, SP-A and C1q, and the expression of their receptor, myosin 18A. These findings reveal the existence within different tissues of an amplification system needed for local type 2 responses. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000402871700054 |
WOS关键词 | SURFACTANT PROTEIN-A ; TISSUE-REPAIR ; POLARIZATION ; RESPONSES ; FIBROSIS ; IMMUNITY ; ROLES ; MICE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196219 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Complutense Madrid, Dept Biochem & Mol Biol 1, E-28040 Madrid, Spain; 2.Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid 28029, Spain; 3.Univ Edinburgh, Sch Biol Sci, Edinburgh EH9 3FL, Midlothian, Scotland; 4.Univ Edinburgh, Sch Clin Sci, Edinburgh EH9 3FL, Midlothian, Scotland; 5.Univ Manchester, Manchester Collaborat Ctr Inflammat Res, Fac Biol Med & Hlth, Manchester M13 9NT, Lancs, England; 6.Univ Autonoma Barcelona, Corp Sanitaria Univ Parc Tauli, Crit Care Ctr, Parc Tauli 1, Sabadell 08208, Spain; 7.Leibniz Ctr Med & Biosci, Res Ctr Borstel, Div Cellular Pneumol, D-23845 Borstel, Germany; 8.Univ Lubeck, Dept Anesthesiol & Intens Care, D-23538 Lubeck, Germany; 9.Penn State Univ, Coll Med, Pulm Immunol & Physiol Lab, Dept Pediat & Microbiol & Immunol, Hershey, PA 17033 USA; 10.Univ Manchester, Manchester Acad Hlth Sci Ctr, Wellcome Ctr Cell Matrix Res, Fac Biol Med & Hlth, Manchester M13 9PT, Lancs, England; 11.Karolinska Inst, Dept Med Solna, S-17176 Stockholm, Sweden |
推荐引用方式 GB/T 7714 | Minutti, Carlos M.,Jackson-Jones, Lucy H.,Garcia-Fojeda, Belen,et al. Local amplifiers of IL-4R alpha-mediated macrophage activation promote repair in lung and liver[J]. SCIENCE,2017,356(6342):1076-1080. |
APA | Minutti, Carlos M..,Jackson-Jones, Lucy H..,Garcia-Fojeda, Belen.,Knipper, Johanna A..,Sutherland, Tara E..,...&Allen, Judith E..(2017).Local amplifiers of IL-4R alpha-mediated macrophage activation promote repair in lung and liver.SCIENCE,356(6342),1076-1080. |
MLA | Minutti, Carlos M.,et al."Local amplifiers of IL-4R alpha-mediated macrophage activation promote repair in lung and liver".SCIENCE 356.6342(2017):1076-1080. |
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