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DOI | 10.1126/science.aal5005 |
Polymeric peptide pigments with sequence-encoded properties | |
Lampel, Ayala1; McPhee, Scott A.1; Park, Hang-Ah2; Scott, Gary G.3,4; Humagain, Sunita5,6,7,8; Hekstra, Doeke R.9; Yoo, Barney10; Frederix, Pim W. J. M.11; Li, Tai-De1; Abzalimov, Rinat R.1; Greenbaum, Steven G.5,6,7,8; Tuttle, Tell3,4; Hu, Chunhua12; Bettinger, Christopher J.2,13,14; Ulijn, Rein V.1,6,7,8,10 | |
2017-06-09 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6342页码:1064-1068 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Scotland; Netherlands |
英文摘要 | Melanins are a family of heterogeneous polymeric pigments that provide ultraviolet (UV) light protection, structural support, coloration, and free radical scavenging. Formed by oxidative oligomerization of catecholic small molecules, the physical properties of melanins are influenced by covalent and noncovalent disorder. We report the use of tyrosine-containing tripeptides as tunable precursors for polymeric pigments. In these structures, phenols are presented in a (supra-)molecular context dictated by the positions of the amino acids in the peptide sequence. Oxidative polymerization can be tuned in a sequence-dependent manner, resulting in peptide sequence-encoded properties such as UV absorbance, morphology, coloration, and electrochemical properties over a considerable range. Short peptides have low barriers to application and can be easily scaled, suggesting near-term applications in cosmetics and biomedicine. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000402871700051 |
WOS关键词 | BIOMATERIALS ; NANOTUBES ; EUMELANIN ; HYDROGELS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196214 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.CUNY, Grad Ctr, Adv Sci Res Ctr, 85 St Nicholas Terrace, New York, NY 10031 USA; 2.Carnegie Mellon Univ, Dept Mat Sci & Engn, 5000 Forbes Ave, Pittsburgh, PA 15213 USA; 3.Univ Strathclyde, WestCHEM, 295 Cathedral St, Glasgow G1 1XL, Lanark, Scotland; 4.Univ Strathclyde, Dept Pure & Appl Chem, 295 Cathedral St, Glasgow G1 1XL, Lanark, Scotland; 5.CUNY, Hunter Coll, Dept Phys & Astron, 695 Pk Ave, New York, NY 10065 USA; 6.CUNY, Grad Ctr, PhD Program Biochem, New York, NY 10016 USA; 7.CUNY, Grad Ctr, PhD Program Chem, New York, NY 10016 USA; 8.CUNY, Grad Ctr, PhD Program Phys, New York, NY 10016 USA; 9.Harvard Univ, Sch Engn & Appl Sci, Dept Mol & Cellular Biol, FAS Ctr Syst Biol, Cambridge, MA 02138 USA; 10.CUNY, Hunter Coll, Dept Chem, 695 Pk Ave, New York, NY 10065 USA; 11.Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Groningen, Netherlands; 12.Silver Ctr Arts & Sci, Dept Chem, 100 Washington Sq East, New York, NY 10003 USA; 13.Carnegie Mellon Univ, Dept Biomed Engn, 5000 Forbes Ave, Pittsburgh, PA 15213 USA; 14.McGowan Inst Regenerat Med, 450 Technol Dr,Suite 300, Pittsburgh, PA 15219 USA |
推荐引用方式 GB/T 7714 | Lampel, Ayala,McPhee, Scott A.,Park, Hang-Ah,et al. Polymeric peptide pigments with sequence-encoded properties[J]. SCIENCE,2017,356(6342):1064-1068. |
APA | Lampel, Ayala.,McPhee, Scott A..,Park, Hang-Ah.,Scott, Gary G..,Humagain, Sunita.,...&Ulijn, Rein V..(2017).Polymeric peptide pigments with sequence-encoded properties.SCIENCE,356(6342),1064-1068. |
MLA | Lampel, Ayala,et al."Polymeric peptide pigments with sequence-encoded properties".SCIENCE 356.6342(2017):1064-1068. |
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