Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aai9383 |
Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women | |
Klatt, Nichole R.1; Cheu, Ryan1; Birse, Kenzie2,3; Zevin, Alexander S.1; Perner, Michelle2,3; Noel-Romas, Laura2,3; Grobler, Anneke4; Westmacott, Garrett5; Xie, Irene Y.2,3; Butler, Jennifer2,3; Mansoor, Leila4; McKinnon, Lyle R.3,4; Passmore, Jo-Ann S.4,6,7; Karim, Quarraisha Abdool4,8; Karim, Salim S. Abdool4,8; Burgener, Adam D.2,3,9 | |
2017-06-02 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6341页码:938-944 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Canada; South Africa; Sweden |
英文摘要 | Antiretroviral-based strategies for HIV prevention have shown inconsistent results in women. We investigated whether vaginal microbiota modulated tenofovir gel microbicide efficacy in the CAPRISA (Centre for the AIDS Program of Research in South Africa) 004 trial. Two-major vaginal bacterial community types-one dominated by Lactobacillus (59.2%) and the other where Gardnerella vaginalis predominated with other anaerobic bacteria (40.8%)-were identified in 688 women profiled. Tenofovir reduced HIV incidence by 61%(P = 0.013) in Lactobacillus-dominant women but only 18% (P = 0.644) in women with non-Lactobacillus bacteria, a threefold difference in efficacy. Detectible mucosal tenofovir was lower in non-Lactobacillus women, negatively correlating with G. vaginalis and other anaerobic bacteria, which depleted tenofovir by metabolism more rapidly than target cells convert to pharmacologically active drug. This study provides evidence linking vaginal bacteria to microbicide efficacy through tenofovir depletion via bacterial metabolism. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000402552300031 |
WOS关键词 | PREEXPOSURE PROPHYLAXIS ; GENITAL-TRACT ; VAGINOSIS ; ACQUISITION ; INFECTION ; RISK ; IDENTIFICATION ; LACTOBACILLI ; TRANSMISSION ; PHARMACOLOGY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196179 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Washington, Dept Pharmaceut, Washington Natl Primate Res Ctr, Seattle, WA 98195 USA; 2.Publ Hlth Agcy Canada, Natl HIV & Retrovirol Labs, JC Wilt Infect Dis Res Ctr, Winnipeg, MB, Canada; 3.Univ Manitoba, Dept Med Microbiol & Infect Dis, Winnipeg, MB, Canada; 4.Univ KwaZulu Natal, Ctr AIDS Program Res South Africa CAPRISA, Durban, South Africa; 5.Publ Hlth Agcy Canada, Natl Microbiol Lab, Mass Spectrometry & Prote Core Facil, Winnipeg, MB, Canada; 6.Univ Cape Town, Inst Infect Dis & Mol Med IDM, Cape Town, South Africa; 7.Natl Hlth Lab Serv, Cape Town, South Africa; 8.Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY 10027 USA; 9.Karolinska Inst, Karolinska Univ Hosp, Infect Dis Unit, Dept Med Solna,Ctr Molecular Med, Stockholm, Sweden |
推荐引用方式 GB/T 7714 | Klatt, Nichole R.,Cheu, Ryan,Birse, Kenzie,et al. Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women[J]. SCIENCE,2017,356(6341):938-944. |
APA | Klatt, Nichole R..,Cheu, Ryan.,Birse, Kenzie.,Zevin, Alexander S..,Perner, Michelle.,...&Burgener, Adam D..(2017).Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women.SCIENCE,356(6341),938-944. |
MLA | Klatt, Nichole R.,et al."Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women".SCIENCE 356.6341(2017):938-944. |
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