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DOI | 10.1126/science.aal3321 |
A subcellular map of the human proteome | |
Thul, Peter J.1; Akesson, Lovisa1; Wiking, Mikaela1; Mahdessian, Diana1; Geladaki, Aikaterini2,3; Blal, Hammou Ait1; Alm, Tove1; Asplund, Anna4; Bjork, Lars1; Breckels, Lisa M.2,5; Backstrom, Anna1; Danielsson, Frida1; Fagerberg, Linn1; Fall, Jenny1; Gatto, Laurent2,5; Gnann, Christian1; Hober, Sophia6; Hjelmare, Martin1; Johansson, Fredric1; Lee, Sunjae1; Lindskog, Cecilia4; Mulder, Jan7; Mulvey, Claire M.2; Nilsson, Peter1; Oksvold, Per1; Rockberg, Johan6; Schutten, Rutger1; Schwenk, Jochen M.1; Sivertsson, Asa1; Sjostedt, Evelina4; Skogs, Marie1; Stadler, Charlotte1; Sullivan, Devin P.1; Tegel, Hanna6; Winsnes, Casper1; Zhang, Cheng1; Zwahlen, Martin1; Mardinoglu, Adil1; Ponten, Fredrik4; von Feilitzen, Kalle1; Lilley, Kathryn S.2; Uhlen, Mathias1; Lundberg, Emma1 | |
2017-05-26 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6340 |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden; England |
英文摘要 | Resolving the spatial distribution of the human proteome at a subcellular level can greatly increase our understanding of human biology and disease. Here we present a comprehensive image-based map of subcellular protein distribution, the Cell Atlas, built by integrating transcriptomics and antibody-based immunofluorescence microscopy with validation by mass spectrometry. Mapping the in situ localization of 12,003 human proteins at a single-cell level to 30 subcellular structures enabled the definition of the proteomes of 13 major organelles. Exploration of the proteomes revealed single-cell variations in abundance or spatial distribution and localization of about half of the proteins to multiple compartments. This subcellular map can be used to refine existing protein-protein interaction networks and provides an important resource to deconvolute the highly complex architecture of the human cell. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000401957900032 |
WOS关键词 | SIGNAL PEPTIDES ; HUMAN PROTEINS ; LOCALIZATION ; SINGLE ; IMMUNOFLUORESCENCE ; VALIDATION ; PREDICTION ; SELECTION ; DYNAMICS ; RESOURCE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196130 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, SE-17121 Stockholm, Sweden; 2.Univ Cambridge, Dept Biochem, Cambridge Ctr Prote, Tennis Court Rd, Cambridge CB2 1QR, England; 3.Univ Cambridge, Dept Genet, Downing St, Cambridge CB2 3EH, England; 4.Uppsala Univ, Sci Life Lab, Genet & Pathol, Dept Immunol, SE-75185 Uppsala, Sweden; 5.Univ Cambridge, Dept Biochem, Computat Prote Unit, Tennis Court Rd, Cambridge CB2 1QR, England; 6.KTH Royal Inst Technol, Sch Biotechnol, Dept Prote, SE-10691 Stockholm, Sweden; 7.Karolinska Inst, Dept Neurosci, Sci Life Lab, SE-17177 Stockholm, Sweden |
推荐引用方式 GB/T 7714 | Thul, Peter J.,Akesson, Lovisa,Wiking, Mikaela,et al. A subcellular map of the human proteome[J]. SCIENCE,2017,356(6340). |
APA | Thul, Peter J..,Akesson, Lovisa.,Wiking, Mikaela.,Mahdessian, Diana.,Geladaki, Aikaterini.,...&Lundberg, Emma.(2017).A subcellular map of the human proteome.SCIENCE,356(6340). |
MLA | Thul, Peter J.,et al."A subcellular map of the human proteome".SCIENCE 356.6340(2017). |
条目包含的文件 | 条目无相关文件。 |
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