Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation

doi:10.1126/science.aam7100

GSTDTAP > 地球科学

DOI	10.1126/science.aam7100
	Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation
	Zhang, Xiaobing; van den Pol, Anthony N.
	2017-05-26
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2017
卷号	356 期号:6340 页码:853-858
文章类型	Article
语种	英语
国家	USA
英文摘要	The neuronal substrate for binge eating, which can at times lead to obesity, is not clear. We find that optogenetic stimulation of mouse zona incerta (ZI) gamma-aminobutyric acid (GABA) neurons or their axonal projections to paraventricular thalamus (PVT) excitatory neurons immediately (in 2 to 3 seconds) evoked binge-like eating. Minimal intermittent stimulation led to body weight gain; ZI GABA neuron ablation reduced weight. ZI stimulation generated 35% of normal 24-hour food intake in just 10 minutes. The ZI cells were excited by food deprivation and the gut hunger signal ghrelin. In contrast, stimulation of excitatory axons from the parasubthalamic nucleus to PVT or direct stimulation of PVT glutamate neurons reduced food intake. These data suggest an unexpected robust orexigenic potential for the ZI GABA neurons.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000401957900040
WOS关键词	PARAVENTRICULAR THALAMIC NUCLEUS ; COMORBIDITY-SURVEY-REPLICATION ; PROTEIN-COUPLED RECEPTORS ; DEEP BRAIN-STIMULATION ; PARKINSONS-DISEASE ; PREVALENCE ; DISORDERS ; HYPOTHALAMUS ; PROJECTIONS ; INJECTIONS
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/196122
专题	地球科学资源环境科学气候变化
作者单位	Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT 06520 USA
推荐引用方式 GB/T 7714	Zhang, Xiaobing,van den Pol, Anthony N.. Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation[J]. SCIENCE,2017,356(6340):853-858.
APA	Zhang, Xiaobing,&van den Pol, Anthony N..(2017).Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation.SCIENCE,356(6340),853-858.
MLA	Zhang, Xiaobing,et al."Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation".SCIENCE 356.6340(2017):853-858.