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DOI | 10.1126/science.aah6895 |
A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568 | |
Yang, Peng1; Wang, Yixuan1,2; Hoang, Don1; Tinkham, Matthew1; Patel, Anamika3; Sun, Ming-An1; Wolf, Gernot1; Baker, Mairead; Chien, Huan-Chieh4,5,6; Lai, Kuan-Yu Nick4,5,6; Cheng, Xiaodong3; Shen, Che-Kun James4,5,6; Macfarlan, Todd S.1 | |
2017-05-19 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6339页码:757-759 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Peoples R China; Taiwan |
英文摘要 | Insulin-like growth factor 2 (IGF2) is the major fetal growth hormone in mammals. We identify zinc finger protein 568 (ZFP568), a member of the rapidly evolving Kruppel-associated box-zinc finger protein (KRAB-ZFP) family linked primarily to silencing of endogenous retroelements, as a direct repressor of a placental-specific Igf2 transcript (designated Igf2-P0) in mice. Loss of Zfp568, which causes gastrulation failure, or mutation of the ZFP568-binding site at the Igf2-P0 promoter causes inappropriate Igf2-P0 activation. Deletion of Igf2 can completely rescue Zfp568 gastrulation phenotypes through late gestation. Our data highlight the exquisite selectivity with which members of the KRAB-ZFP family repress their targets and identify an additional layer of transcriptional control of a key growth factor regulating fetal and placental development. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000401508400049 |
WOS关键词 | CONVERGENT EXTENSION ; GENE ; METHYLATION ; TISSUES ; REGION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196090 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD 20892 USA; 2.Tongji Univ, Shanghai Matern & Infant Hosp 1, Clin & Translat Res Ctr, Sch Life Sci & Technol, Shanghai 200092, Peoples R China; 3.Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA; 4.Natl Yang Ming Univ, Dept Life Sci, Taipei, Taiwan; 5.Natl Yang Ming Univ, Inst Genome Sci, Taipei, Taiwan; 6.Acad Sinica, Inst Mol Biol, Taipei, Taiwan |
推荐引用方式 GB/T 7714 | Yang, Peng,Wang, Yixuan,Hoang, Don,et al. A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568[J]. SCIENCE,2017,356(6339):757-759. |
APA | Yang, Peng.,Wang, Yixuan.,Hoang, Don.,Tinkham, Matthew.,Patel, Anamika.,...&Macfarlan, Todd S..(2017).A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568.SCIENCE,356(6339),757-759. |
MLA | Yang, Peng,et al."A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568".SCIENCE 356.6339(2017):757-759. |
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