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DOI | 10.1126/science.aai8185 |
Three-dimensional Ca2+ imaging advances understanding of astrocyte biology | |
Bindocci, Erika; Savtchouk, Iaroslav; Liaudet, Nicolas; Becker, Denise; Carriero, Giovanni; Volterra, Andrea | |
2017-05-19 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6339 |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland |
英文摘要 | Astrocyte communication is typically studied by two-dimensional calcium ion (Ca2+) imaging, but this method has not yielded conclusive data on the role of astrocytes in synaptic and vascular function. We developed a three-dimensional two-photon imaging approach and studied Ca2+ dynamics in entire astrocyte volumes, including during axon-astrocyte interactions. In both awake mice and brain slices, we found that Ca2+ activity in an individual astrocyte is scattered throughout the cell, largely compartmented between regions, preponderantly local within regions, and heterogeneously distributed regionally and locally. Processes and endfeet displayed frequent fast activity, whereas the soma was infrequently active. In awake mice, activity was higher than in brain slices, particularly in endfeet and processes, and displayed occasional multifocal cellwide events. Astrocytes responded locally to minimal axonal firing with time-correlated Ca2+ spots. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000401508400037 |
WOS关键词 | RESPONSES ; DYNAMICS ; CORTEX ; VASODILATION ; MODULATION ; ACTIVATION ; TRANSIENT ; RELEASE ; SIGNALS ; CELLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196089 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Univ Lausanne, Dept Fundamental Neurosci, CH-1005 Lausanne, Switzerland |
推荐引用方式 GB/T 7714 | Bindocci, Erika,Savtchouk, Iaroslav,Liaudet, Nicolas,et al. Three-dimensional Ca2+ imaging advances understanding of astrocyte biology[J]. SCIENCE,2017,356(6339). |
APA | Bindocci, Erika,Savtchouk, Iaroslav,Liaudet, Nicolas,Becker, Denise,Carriero, Giovanni,&Volterra, Andrea.(2017).Three-dimensional Ca2+ imaging advances understanding of astrocyte biology.SCIENCE,356(6339). |
MLA | Bindocci, Erika,et al."Three-dimensional Ca2+ imaging advances understanding of astrocyte biology".SCIENCE 356.6339(2017). |
条目包含的文件 | 条目无相关文件。 |
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