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DOI | 10.1126/science.aai9264 |
Ephrin B1-mediated repulsion and signaling control germinal center T cell territoriality and function | |
Lu, Peiwen1,2,3; Shih, Changming1,2,3; Qi, Hai1,2,3,4 | |
2017-05-19 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6339 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | Follicular T helper (T-FH) cells orchestrate the germinal center (GC) reaction locally. Local mechanisms regulating their dynamics and helper functions are not well defined. Here we found that GC-expressed ephrin B1 (EFNB1) repulsively inhibited T cell to B cell adhesion and GC T-FH retention by signaling through T-FH-expressed EPHB6 receptor. At the same time, EFNB1 promoted interleukin-21 production from GC T-FH cells by signaling predominantly through EPHB4. Consequently, EFNB1-null GCs were associated with defective production of plasma cells despite harboring excessive T-FH cells. In a competitive GC reaction, EFNB1-deficient B cells more efficiently interacted with T-FH cells and produced more bone-marrow plasma cells, likely as a result of gaining more contact-dependent help. Our results reveal a contact-dependent repulsive guidance system that controls GC T-FH dynamics and effector functions locally. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000401508400038 |
WOS关键词 | FOLLICULAR HELPER-CELLS ; CENTER B-CELLS ; EPHB6 RECEPTOR ; LYMPH-NODE ; MIGRATION ; TISSUE ; RESPONSES ; ACTIVATION ; PHYSIOLOGY ; EXPRESSION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196088 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Tsinghua Univ, Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China; 2.Tsinghua Univ, Inst Immunol, Lab Dynam Immunobiol, Beijing 100084, Peoples R China; 3.Tsinghua Univ, Sch Med, Dept Basic Med Sci, Beijing 100084, Peoples R China; 4.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China |
推荐引用方式 GB/T 7714 | Lu, Peiwen,Shih, Changming,Qi, Hai. Ephrin B1-mediated repulsion and signaling control germinal center T cell territoriality and function[J]. SCIENCE,2017,356(6339). |
APA | Lu, Peiwen,Shih, Changming,&Qi, Hai.(2017).Ephrin B1-mediated repulsion and signaling control germinal center T cell territoriality and function.SCIENCE,356(6339). |
MLA | Lu, Peiwen,et al."Ephrin B1-mediated repulsion and signaling control germinal center T cell territoriality and function".SCIENCE 356.6339(2017). |
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