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DOI | 10.1126/science.aah3862 |
Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals | |
Grillo, Anthony S.1; SantaMaria, Anna M.2; Kafina, Martin D.3; Cioffi, Alexander G.2; Huston, Nicholas C.3; Han, Murui4; Seo, Young Ah5; Yien, Yvette Y.3; Nardone, Christopher2; Menon, Archita V.4; Fan, James1; Svoboda, Dillon C.2; Anderson, Jacob B.1; Hong, John D.1; Nicolau, Bruno G.1; Subedi, Kiran1; Gewirth, Andrew A.1; Wessling-Resnick, Marianne6; Kim, Jonghan4; Paw, Barry H.3,7,8; Burke, Martin D.1,2,9 | |
2017-05-12 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6338页码:608-616 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Multiple human diseases ensue from a hereditary or acquired deficiency of iron-transporting protein function that diminishes transmembrane iron flux in distinct sites and directions. Because other iron-transport proteins remain active, labile iron gradients build up across the corresponding protein-deficient membranes. Here we report that a small-molecule natural product, hinokitiol, can harness such gradients to restore iron transport into, within, and/or out of cells. The same compound promotes gut iron absorption in DMT1-deficient rats and ferroportin-deficient mice, as well as hemoglobinization in DMT1-and mitoferrin-deficient zebrafish. These findings illuminate a general mechanistic framework for small molecule-mediated site-and direction-selective restoration of iron transport. They also suggest that small molecules that partially mimic the function of missing protein transporters of iron, and possibly other ions, may have potential in treating human diseases. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000400975200049 |
WOS关键词 | STRUCTURAL-CHARACTERIZATION ; POSITIONAL CLONING ; METAL HOMEOSTASIS ; MEDICAL PROGRESS ; BETA-THUJAPLICIN ; HINOKITIOL ; INSIGHTS ; CELLS ; DISORDERS ; COMPLEXES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196026 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Illinois, Dept Chem, Urbana, IL 61801 USA; 2.Univ Illinois, Dept Biochem, Urbana, IL 61801 USA; 3.Harvard Med Sch, Brigham & Womens Hosp, Div Hematol, Dept Med, Boston, MA 02115 USA; 4.Northeastern Univ, Dept Pharmaceut Sci, Boston, MA 02115 USA; 5.Univ Michigan, Dept Nutr Sci, Sch Publ Hlth, Ann Arbor, MI 48109 USA; 6.Harvard TH Chan Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA; 7.Harvard Med Sch, Boston Childrens Hosp, Div Hematol Oncol, Dept Med, Boston, MA 02115 USA; 8.Harvard Med Sch, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02215 USA; 9.Univ Illinois, Carle Illinois Coll Med, Champaign, IL 61820 USA |
推荐引用方式 GB/T 7714 | Grillo, Anthony S.,SantaMaria, Anna M.,Kafina, Martin D.,et al. Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals[J]. SCIENCE,2017,356(6338):608-616. |
APA | Grillo, Anthony S..,SantaMaria, Anna M..,Kafina, Martin D..,Cioffi, Alexander G..,Huston, Nicholas C..,...&Burke, Martin D..(2017).Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals.SCIENCE,356(6338),608-616. |
MLA | Grillo, Anthony S.,et al."Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals".SCIENCE 356.6338(2017):608-616. |
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