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DOI | 10.1126/science.aah6152 |
Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis | |
Caldieri, Giusi1; Barbieri, Elisa1; Nappo, Gilda1; Raimondi, Andrea4; Bonora, Massimo6,7; Conte, Alexia1; Verhoef, Lisette G. G. C.1,8; Confalonieri, Stefano1; Malabarba, Maria Grazia1,2; Bianchi, Fabrizio3,9; Cuomo, Alessandro3; Bonaldi, Tiziana3; Martini, Emanuele1; Mazza, Davide; Pinton, Paolo6,7; Tacchetti, Carlo4,5; Polo, Simona1,2; Di Fiore, Pier Paolo1,2,3; Sigismund, Sara1 | |
2017-05-12 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6338页码:617-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Italy |
英文摘要 | The integration of endocytic routes is critical to regulate receptor signaling. A nonclathrin endocytic (NCE) pathway of the epidermal growth factor receptor (EGFR) is activated at high ligand concentrations and targets receptors to degradation, attenuating signaling. Here we performed an unbiased molecular characterization of EGFR-NCE. We identified NCE-specific regulators, including the endoplasmic reticulum (ER)-resident protein reticulon 3 (RTN3) and a specific cargo, CD147. RTN3 was critical for EGFR/CD147-NCE, promoting the creation of plasma membrane (PM)-ER contact sites that were required for the formation and/or maturation of NCE invaginations. Ca2+ release at these sites, triggered by inositol 1,4,5-trisphosphate (IP3)-dependent activation of ER Ca2+ channels, was needed for the completion of EGFR internalization. Thus, we identified a mechanism of EGFR endocytosis that relies on ER-PM contact sites and local Ca2+ signaling. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000400975200050 |
WOS关键词 | CLATHRIN-INDEPENDENT ENDOCYTOSIS ; TUBULAR ENDOPLASMIC-RETICULUM ; PLASMA-MEMBRANE ; PROTEINS ; INTERNALIZATION ; EXPRESSION ; PATHWAY ; CELLS ; ENDOSOMES ; PITS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196023 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Fdn Ist FIRC Oncol Mol IFOM, Via Adamello 16, I-20139 Milan, Italy; 2.Univ Milan, Dipartimento Oncol & Ematooncol DiPO, Via Festa Perdono 7, I-20122 Milan, Italy; 3.Ist Europeo Oncol, Via Ripamonti 435, I-20141 Milan, Italy; 4.Ist Sci San Raffaele, Ctr Imaging Sperimentale, Via Olgettina 52, I-20132 Milan, Italy; 5.Univ Genoa, Dipartimento Med Sperimentale, Genoa, Italy; 6.Univ Ferrara, Sect Pathol Oncol & Expt Biol, Dept Morphol Surg & Expt Med, Ferrara, Italy; 7.Univ Ferrara, Lab Technol Adv Therapies Ctr, Dept Morphol Surg & Expt Med, Ferrara, Italy; 8.Ist Italiano Tecnol, Ctr Genom Sci IIT SEMM, Via Adamello 16, I-20139 Milan, Italy; 9.Casa Sollievo Sofferenza, SBReMIT Inst Stem Cell Biol Regenerat Med & Innov, Viale Cappuccini Snc, I-71013 Foggia, Italy |
推荐引用方式 GB/T 7714 | Caldieri, Giusi,Barbieri, Elisa,Nappo, Gilda,et al. Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis[J]. SCIENCE,2017,356(6338):617-+. |
APA | Caldieri, Giusi.,Barbieri, Elisa.,Nappo, Gilda.,Raimondi, Andrea.,Bonora, Massimo.,...&Sigismund, Sara.(2017).Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis.SCIENCE,356(6338),617-+. |
MLA | Caldieri, Giusi,et al."Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis".SCIENCE 356.6338(2017):617-+. |
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