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DOI | 10.1126/science.aam5498 |
Male sex in houseflies is determined by Mdmd, a paralog of the generic splice factor gene CWC22 | |
Sharma, Akash1,2; Heinze, Svenia D.2; Wu, Yanli1,3; Kohlbrenner, Tea2; Morilla, Ian2,5; Brunner, Claudia2; Wimmer, Ernst A.3; van de Zande, Louis1; Robinson, Mark D.2,4; Beukeboom, Leo W.1; Bopp, Daniel2 | |
2017-05-12 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6338页码:642-645 |
文章类型 | Article |
语种 | 英语 |
国家 | Netherlands; Switzerland; Germany; France |
英文摘要 | Across species, animals have diverse sex determination pathways, each consisting of a hierarchical cascade of genes and its associated regulatory mechanism. Houseflies have a distinctive polymorphic sex determination system in which a dominant male determiner, the M-factor, can reside on any of the chromosomes. We identified a gene, Musca domestica male determiner (Mdmd), as the M-factor. Mdmd originated from a duplication of the spliceosomal factor gene CWC22 (nucampholin). Targeted Mdmd disruption results in complete sex reversal to fertile females because of a shift from male to female expression of the downstream genes transformer and doublesex. The presence of Mdmd on different chromosomes indicates that Mdmd translocated to different genomic sites. Thus, an instructive signal in sex determination can arise by duplication and neofunctionalization of an essential splicing regulator. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000400975200056 |
WOS关键词 | EXON JUNCTION COMPLEX ; MUSCA-DOMESTICA L ; DETERMINING MECHANISMS ; X-CHROMOSOME ; INSECTS ; POPULATIONS ; RATIO |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196020 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Groningen, Groningen Inst Evolutionary Life Sci, Post Off Box 11103, NL-9700 CC Groningen, Netherlands; 2.Univ Zurich, Inst Mol Life Sci, CH-8057 Zurich, Switzerland; 3.Univ Goettingen, Gottingen Ctr Mol Biosci, Dept Dev Biol, Johann Friedrich Blumenbach Inst Zool & Anthropol, Gottingen, Germany; 4.Univ Zurich, SIB, Zurich, Switzerland; 5.Univ Paris 13 Sorbonne, Lab Inflamex, LAGA, INSERM,UMR 1149, Paris, France |
推荐引用方式 GB/T 7714 | Sharma, Akash,Heinze, Svenia D.,Wu, Yanli,et al. Male sex in houseflies is determined by Mdmd, a paralog of the generic splice factor gene CWC22[J]. SCIENCE,2017,356(6338):642-645. |
APA | Sharma, Akash.,Heinze, Svenia D..,Wu, Yanli.,Kohlbrenner, Tea.,Morilla, Ian.,...&Bopp, Daniel.(2017).Male sex in houseflies is determined by Mdmd, a paralog of the generic splice factor gene CWC22.SCIENCE,356(6338),642-645. |
MLA | Sharma, Akash,et al."Male sex in houseflies is determined by Mdmd, a paralog of the generic splice factor gene CWC22".SCIENCE 356.6338(2017):642-645. |
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