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DOI | 10.1126/science.aai8801 |
Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly | |
Mountoufaris, George1; 39;Keeffe, Sean2 | |
2017-04-28 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6336页码:411-413 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The vertebrate clustered protocadherin (Pcdh) cell surface proteins are encoded by three closely linked gene clusters (Pcdh alpha, Pcdh beta, and Pcdh gamma). Here, we show that all three gene clusters functionally cooperate to provide individual mouse olfactory sensory neurons (OSNs) with the cell surface diversity required for their assembly into distinct glomeruli in the olfactory bulb. Although deletion of individual Pcdh clusters had subtle phenotypic consequences, the loss of all three clusters (tricluster deletion) led to a severe axonal arborization defect and loss of self-avoidance. By contrast, when endogenous Pcdh diversity is overridden by the expression of a single-tricluster gene repertoire (alpha and beta and gamma), OSN axons fail to converge to form glomeruli, likely owing to contact-mediated repulsion between axons expressing identical combinations of Pcdh isoforms. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000400143000047 |
WOS关键词 | GAMMA-PROTOCADHERINS ; SENSORY NEURONS ; SELF-RECOGNITION ; GENE-EXPRESSION ; ALPHA ; COALESCENCE ; RECEPTORS ; PROMOTER ; SURVIVAL ; CLUSTER |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195933 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Columbia Univ, Dept Biochem & Mol Biophys, 630 W 168th St, New York, NY 10032 USA; 2.Columbia Univ, Mortimer B Zuckerman Mind Brain Behav Inst, New York, NY 10032 USA; 3.Columbia Univ, Kavli Inst Brain Sci, Dept Neurosci, New York, NY 10032 USA; 4.Kallyope Inc, New York, NY 10016 USA |
推荐引用方式 GB/T 7714 | Mountoufaris, George,39;Keeffe, Sean. Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly[J]. SCIENCE,2017,356(6336):411-413. |
APA | Mountoufaris, George,&39;Keeffe, Sean.(2017).Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly.SCIENCE,356(6336),411-413. |
MLA | Mountoufaris, George,et al."Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly".SCIENCE 356.6336(2017):411-413. |
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