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DOI | 10.1126/science.aal3231 |
Pcdh alpha c2 is required for axonal tiling and assembly of serotonergic circuitries in mice | |
Chen, Weisheng V.1; 39;Keeffe, Sean2 | |
2017-04-28 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6336页码:406-410 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Peoples R China |
英文摘要 | Serotonergic neurons project their axons pervasively throughout the brain and innervate various target fields in a space-filling manner, leading to tiled arrangements of their axon terminals to allow optimal allocation of serotonin among target neurons. Here we show that conditional deletion of the mouse protocadherin a (Pcdha) gene cluster in serotonergic neurons disrupts local axonal tiling and global assembly of serotonergic circuitries and results in depression-like behaviors. Genetic dissection and expression profiling revealed that this role is specifically mediated by Pcdhac2, which is the only Pcdha isoform expressed in serotonergic neurons. We conclude that, in contrast to neurite self-avoidance, which requires single-cell identity mediated by Pcdh diversity, a single cell-type identity mediated by the common C-type Pcdh isoform is required for axonal tiling and assembly of serotonergic circuitries. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000400143000046 |
WOS关键词 | PROTOCADHERIN-ALPHA FAMILY ; GAMMA-PROTOCADHERINS ; EXPRESSION ; DIVERSITY ; SURVIVAL ; NEURONS ; CLUSTER ; BETA |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195929 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Columbia Univ, Dept Biochem & Mol Biophys, 630 W 168th St, New York, NY 10032 USA; 2.Columbia Univ, Mortimer B Zuckerman Mind Brain Behav Inst, New York, NY 10027 USA; 3.Columbia Univ, Dept Psychiat, New York, NY 10032 USA; 4.Res Fdn Mental Hyg, Div Integrat Neurosci, New York, NY 10032 USA; 5.Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA; 6.Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA; 7.Columbia Univ, Dept Neurosci, New York, NY 10032 USA; 8.Columbia Univ, Dept Pharmacol, New York, NY 10032 USA; 9.Shanghai Jiao Tong Univ, Ctr Comparat Biomed, Shanghai 200240, Peoples R China; 10.Kallyope, New York, NY 10016 USA |
推荐引用方式 GB/T 7714 | Chen, Weisheng V.,39;Keeffe, Sean. Pcdh alpha c2 is required for axonal tiling and assembly of serotonergic circuitries in mice[J]. SCIENCE,2017,356(6336):406-410. |
APA | Chen, Weisheng V.,&39;Keeffe, Sean.(2017).Pcdh alpha c2 is required for axonal tiling and assembly of serotonergic circuitries in mice.SCIENCE,356(6336),406-410. |
MLA | Chen, Weisheng V.,et al."Pcdh alpha c2 is required for axonal tiling and assembly of serotonergic circuitries in mice".SCIENCE 356.6336(2017):406-410. |
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