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DOI | 10.1126/science.aam5298 |
Ancient genomic changes associated with domestication of the horse | |
Librado, Pablo1; Gamba, Cristina1; Gaunitz, Charleen1; Sarkissian, Clio Der1; Pruvost, Melanie2; Albrechtsen, Anders3; Fages, Antoine1,4; Khan, Naveed1,5; Schubert, Mikkel1; Jagannathan, Vidhya6; Serres-Armero, Aitor7,8; Kuderna, Lukas F. K.7,8; Povolotskaya, Inna S.7,8; Seguin-Orlando, Andaine1,9; Lepetz, Sebastien10; Neuditschko, Markus11; Theves, Catherine4; Alquraishi, Saleh12; Alfarhan, Ahmed H.12; Al-Rasheid, Khaled12; Rieder, Stefan11; Samashev, Zainolla13; Francfort, Henri-Paul14; Benecke, Norbert15; Hofreiter, Michael16; Ludwig, Arne17; Keyser, Christine4,18; Marques-Bonet, Tomas7,8,19; Ludes, Bertrand4,20; Crubezy, Eric4; Leeb, Tosso6; Willerslev, Eske1; Orlando, Ludovic1,4 | |
2017-04-28 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6336页码:442-445 |
文章类型 | Article |
语种 | 英语 |
国家 | Denmark; France; Pakistan; Switzerland; Spain; Saudi Arabia; Kazakhstan; Germany |
英文摘要 | The genomic changes underlying both early and late stages of horse domestication remain largely unknown. We examined the genomes of 14 early domestic horses from the Bronze and Iron Ages, dating to between similar to 4.1 and 2.3 thousand years before present. We find early domestication selection patterns supporting the neural crest hypothesis, which provides a unified developmental origin for common domestic traits. Within the past 2.3 thousand years, horses lost genetic diversity and archaic DNA tracts introgressed from a now-extinct lineage. They accumulated deleterious mutations later than expected under the cost-of-domestication hypothesis, probably because of breeding from limited numbers of stallions. We also reveal that Iron Age Scythian steppe nomads implemented breeding strategies involving no detectable inbreeding and selection for coat-color variation and robust forelimbs. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000400143000055 |
WOS关键词 | COMPLETE MITOCHONDRIAL GENOME ; WIDE SNP-ASSOCIATION ; COAT COLOR ; MISSENSE MUTATION ; POPULATION-GENETICS ; PHYLOGENETIC ANALYSIS ; SPOTTING PATTERN ; READ ALIGNMENT ; DNA EXTRACTION ; RECEPTOR GENE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195926 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Nat Hist Museum Denmark, Ctr GeoGenet, Oster Voldgade 5-7, DK-1350 Copenhagen K, Denmark; 2.Univ Paris Diderot, CNRS, UMR 7592, Inst Jacques Monod, F-75205 Paris 13, France; 3.Univ Copenhagen, Dept Biol, Bioinformat Ctr, DK-2200 Copenhagen N, Denmark; 4.Univ Paul Sabatier, Univ Toulouse, Lab Anthropobiol Mol & Imagerie Synth, CNRS,UMR 5288, F-31000 Toulouse, France; 5.Abdul Wali Khan Univ, Dept Biotechnol, Mardan, Pakistan; 6.Univ Bern, Inst Genet, CH-3001 Bern, Switzerland; 7.Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Inst Evolutionary Biol CSIC UPF, Barcelona 08003, Spain; 8.Barcelona Inst Sci & Technol, Ctr Genom Regulat CNAG CRG, Baldiri & Reixac 4, Barcelona 08028, Spain; 9.Natl High Throughput DNA Sequencing Ctr, Copenhagen, Denmark; 10.Sorbonne Univ, CNRS, Museum Natl Hist Nat, Archeozool Archeobot Soc Prat & Environm UMR 7209, 55 Rue Buffon, F-75005 Paris, France; 11.Swiss Natl Stud Farm, Agroscope, CH-1580 Avenches, Switzerland; 12.King Saud Univ, Coll Sci, Zool Dept, Riyadh 11451, Saudi Arabia; 13.Branch Inst Archaeol Margulan, Republ Ave 24-405, Astana 010000, Kazakhstan; 14.CNRS, UMR Archeol & Sci Antiqu, Archeol Asie Cent, Maison Rene Ginouves, 21 Allee Univ, F-92023 Nanterre, France; 15.German Archaeol Inst, Dept Nat Sci, D-14195 Berlin, Germany; 16.Univ Potsdam, Fac Math & Nat Sci, Inst Biochem & Biol, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany; 17.Leibniz Inst Zoo & Wildlife Res, Dept Evolutionary Genet, D-10315 Berlin, Germany; 18.Univ Strasbourg, Inst Med Legale, Strasbourg, France; 19.Catalan Inst Res & Adv Studies ICREA, Passeig Lluis Co 23, Barcelona 08010, Spain; 20.Univ Paris 05, Inst Med Legal, Paris, France |
推荐引用方式 GB/T 7714 | Librado, Pablo,Gamba, Cristina,Gaunitz, Charleen,et al. Ancient genomic changes associated with domestication of the horse[J]. SCIENCE,2017,356(6336):442-445. |
APA | Librado, Pablo.,Gamba, Cristina.,Gaunitz, Charleen.,Sarkissian, Clio Der.,Pruvost, Melanie.,...&Orlando, Ludovic.(2017).Ancient genomic changes associated with domestication of the horse.SCIENCE,356(6336),442-445. |
MLA | Librado, Pablo,et al."Ancient genomic changes associated with domestication of the horse".SCIENCE 356.6336(2017):442-445. |
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